Target | Representative compound* | Structure | Reference |
---|
MEK | Trametinib |
| [155, 156] |
MEK | Selumetinib |
| [155,156,157] |
MEK | PD0325901 |
| [155] |
AKT | Uprosertib (GSK2141795) |
| [158] |
AKT | Capivasertib (AZD5363) |
| [158] |
AXL | Cabozantinib |
| [159] |
AXL | DS-1205b |
| [160] |
AXL | Yuanhuadine (YD) |
| [161] |
AXL | Bemcentinib (R428) |
| [162] |
ACK1 | (R)-9b |
| [163, 164] |
- *Osimertinib is a representative third-generation EGFR-TKI