Fig. 4
From: Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Schematic illustration of the mitochondria-targeting strategies and their anticancer effect. Integrated therapeutics include, but are not limited to, PTT, PDT, and CDT. Their function requires the rational design, functionalization, and application of diverse mitochondria-targeting units, such as organic phosphine/sulfur salts, QA salts, transition metal complexes, and MTPs. The generation of superoxide (·O2−), singlet oxygen (1O2), ·OH or heat results in mitochondrial damage, thus inhibiting energy supply and triggering cancer cells death