Table 4 Hypoxia-selective chemical bond-triggered nanoplatforms
Type of chemical bond | Therapeutic agent | Therapy method | Tumor model | Refs. |
|---|---|---|---|---|
Nitro | DOX/CP-NI NPs | Chemotherapy, PDT | Cervical carcinoma | [505] |
DOX@HMs | Chemotherapy, RT | Breast cancer | [506] | |
DOX/FOBD liposome | Chemotherapy | Cervical cancer | [507] | |
HRNP/siRNA | Chemotherapy | Breast cancer | [286] | |
HC/PN/DOX NPs | Chemotherapy, PDT | Lung cancer | [508] | |
NCs/DOX + Ce6 micelles | Chemotherapy, PDT | Breast cancer | [509] | |
ALP-(MIs)n/DOX | Chemotherapy, RT | Glioma | [510] | |
Gd-Au DENPs-Nit | RT | Nasopharyngeal carcinoma | [511] | |
Azo | DOX@AMOFs@ DRHC/CPPs | Chemotherapy | Breast cancer | [306] |
mPEG-AzoPAsp-IM micelles | PDT | Lewis lung carcinoma | [294] | |
DOX@NP | Chemotherapy | Lung cancer | [512] | |
CPs-CPT-Ce6 NPs | Chemotherapy, PDT | Cervical carcinoma | [300] | |
PEG-Azo-PEI-DOPE | Chemotherapy | Cervical carcinoma | [513] | |
CAGE | Immunotherapy, PDT | Melanoma | [514] | |
ALN-HR-PMs/DOX | Chemotherapy | Prostate cancer | [320] | |
N-oxide | TPZ/UCSs | Photodynamic/Chemo/ immunotherapy | Colorectal cancer | [515] |
HAS-GOx-Fe3+-TA (HGTFT) | Chemotherapy, CDT | Breast cancer | [516] | |
TENAB NPs | Chemotherapy, PTT, PDT | Cervical carcinoma | [517] | |
Lip/Ce6/TPZ NPs | Chemotherapy, PDT | Breast cancer | [518] | |
UiO-66-H-P NMOFs | Chemotherapy, PDT | Glioblastoma | [519] | |
HA@AQ4N-Cu (II)-gossypol NPs | Chemotherapy | Prostatic cancer | [520] | |
YS-DMONs-AQ4N- GOx | Chemotherapy | Prostatic cancer | [326] | |
Mn-APPMSF | Chemotherapy, PTT | Hepatocellular carcinoma | [521] | |
AQ4N-64Cu-hCe6- liposome | Chemotherapy, PDT | Breast cancer | [325] |