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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity

Fig. 3

Metabolic determinants for Treg migration. Tregs exhibit increased glycolysis during migration. 1 CCR4 and CCR8 contribute to Treg abundance in the TME. 2 The PI3K-AKT-mTORC2 axis promotes glycolysis by activating GCK, which also interacts with actin to enhance cytoskeletal rearrangements during migration. Additionally, the PI3K-Akt-mTORC2 pathway inhibits CCR7, CD62L, and S1P1 by suppressing the FoxO1 and FoxO3 transcription factors, thereby strongly influencing Treg migration in a way that favors Treg access to peripheral nonlymphoid organs while impairing their recirculation in lymphoid organs. 3 PPAR-γ plays an important role in driving the recruitment of Treg cells to sites of inflammation. GCK glucokinase, S1P1 sphingosine-1-phosphate receptor 1, FoxO1/3 Forkhead Box O1/3, PPAR-γ peroxisome proliferator-activated receptor-γ

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Journal of Hematology & Oncology

ISSN: 1756-8722

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