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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Revealing the evolution of the tumor immune microenvironment in follicular lymphoma patients progressing within 24 months using single-cell imaging mass cytometry

Fig. 2

Evolution of FL and immune cell interactions during POD24 in FL (A), scheme of analysis of interactions between FL and three types of immune cells. Total eight interaction patterns are proposed in the table (right) according to the colocation of FL and immune cells. The fractions of FL-cells with different interactions accounting for total FL-cells were calculated. Higher percentages of FL-cells exclusively interacting with Mφs were shown in Pattern 4 (B), while those simultaneously interacting with Mφs and Tregs were shown in Pattern 7 (C) in the follicles during POD24 in FL. A significant decrease in FL-cells exclusively interacting with CD8+T cells was shown in Pattern 2 (D) after POD24. Additionally, in the peri-follicular regions, decreased FL-cells exclusively interacting with CD8+T cells were shown in Pattern 2 (E), whereas more FL-cells exclusively interacting with Mφs were shown in Pattern 4 (F) during POD24 in FL (*p < 0.05, **p < 0.01, ***p < 0.001)

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Journal of Hematology & Oncology

ISSN: 1756-8722

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