Fig. 1
From: Targeting macrophages in hematological malignancies: recent advances and future directions
An overview of normal hematopoiesis and possible immune escape mechanisms for blood cancers: normally, hematopoietic stem cells (HSCs) develop, in a fate-determined manner, into spectrum-specific hematopoietic progenitor cells, which then differentiate into relative terminal cells. The terminal cells maintain stable hematopoietic development. Inevitably, some precancerous cells appear during the development of the hematopoietic system, but are normally cleared by the immune system. However, precancerous cells can develop into various kinds of hematological malignancies when the immune system is compromised by T cells, B cells, NK cells, MDSC, TAM, and so on