Table 3 General characteristics of the bispecific antibody technology platforms
From: Targeting macrophages in hematological malignancies: recent advances and future directions
With Fc fragments | Without Fc fragments | |
|---|---|---|
Advantages | CMC: Better solubility Better stability Therapeutic effect: Including ADCC and CDC effects, multiple mechanisms to enhance cancer-killing effect Longer half-life | CMC: Easy to produce High productivity Small molecular weight Therapeutic effect: The therapeutic effect is only through antigen binding, with low immunogenicity and fewer side effects |
Disadvantages | Some structural CMCs are more complex, mostly with higher aggregation, mismatch and low purification rates If the molecular weight is too large, the permeability to the tumor tissue will be poor | Need to develop specific purification technology routes Shorter half-life, higher dosing frequency and poor patient tolerance |