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Table 3 General characteristics of the bispecific antibody technology platforms

From: Targeting macrophages in hematological malignancies: recent advances and future directions

  With Fc fragments Without Fc fragments
Advantages CMC:
Better solubility
Better stability
Therapeutic effect:
Including ADCC and CDC effects, multiple mechanisms to enhance cancer-killing effect
Longer half-life
CMC:
Easy to produce
High productivity
Small molecular weight
Therapeutic effect:
The therapeutic effect is only through antigen binding, with low immunogenicity and fewer side effects
Disadvantages Some structural CMCs are more complex, mostly with higher aggregation, mismatch and low purification rates
If the molecular weight is too large, the permeability to the tumor tissue will be poor
Need to develop specific purification technology routes
Shorter half-life, higher dosing frequency and poor patient tolerance