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Table 6 Univariate and multivariate logistic regression analyses with thrombosis and bleeding as dependent variable

From: Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL

Variable

Univariate

Multivariate

OR

95% CI for OR

p

OR

95% CI for OR

p

Thrombosis

      

Steroids for COVID-19

5.141

1.220–21.665

0.026

   

Anti-IL6 or anti-IL6R

3.744

1.942–7.215

< 0.001

2.654

1.182–5.958

0.018

Admission to ICU

3.086

1.707–5.578

< 0.001

   

D-dimer (×times the ULN)

1.016

1.006–1.027

0.002

1.022

1.007–1.038

0.005

CAR

1.030

1.007–1.052

0.009

1.025

1.001–1.051

0.042

Thromboprophylaxis

0.428

0.184–0.996

0.049

0.199

0.061–0.645

0.007

Other cardiovascular diseases

2.316

1.000–5.366

0.050

   

Continued vs. stopped BTKi

1.157

0.433–3.092

0.772

   

Bleeding

      

Age

1.055

1.012–1.100

0.012

1.062

1.017–1.109

0.007

Convalescent hyperimmune plasma use

3.821

1.275–11.450

0.017

   

LMWH intermediate/therapeutic dose use

2.150

0.917–5.041

0.078

2.438

1.023–5.813

0.044

Continued vs. stopped BTKi

1.086

0.342–3.452

0.888

   
  1. IL-6 interleukin 6, ULN upper limit of normal, CAR C-reactive protein to albumin ratio, LMWH low molecular weight heparin, BTKi Bruton tyrosine kinase inhibitors
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Journal of Hematology & Oncology

ISSN: 1756-8722

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