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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: ASXL1/2 mutations and myeloid malignancies

Fig. 1

Conserved domains of the ASXL family. The N-terminal ASXN domain, ASXH and ASXM domains and the C-terminal plant homeodomain (PHD) are highly conserved in the ASXL family. The HARE-HTH motif in ASXN is a putative DNA binding domain. The ASXH domain contains a DEUBAD domain that activates BAP1 to deubiquitinate H2AK119. The LVxxLL motif in the ASXM2 domain is the binding motif for nuclear hormone receptors (NHRs) and the C-terminal PHD domain is a putative histone-recognition module

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