Mutations | IDHWT | IDH1mut | IDH2mut | p-Value |
---|---|---|---|---|
ASXL1 n/N (%) | 46/1187 (3.9) | 5/115 (4.3) | 14/180 (7.8) | .059 |
BCOR n/N (%) | 30/1187 (2.5) | 3/115 (2.6) | 8/180 (4.4) | .342 |
BCORL1 n/N (%) | 26/1187 (2.2) | 3/115 (2.6) | 7/180 (3.9) | .383 |
CBL n/N (%) | 14/1187 (1.2) | 2/115 (1.7) | 3/180 (1.7) | .779 |
CEBPA biallelic (%) | 136/2129 (6.4) | 1/195 (0.5) | 3/274 (1.1) | < .001 |
CSF3R n/N (%) | 13/1187 (1.1) | 2/115 (1.7) | 2/180 (1.1) | .825 |
CUX1 n/N (%) | 22/1187 (1.9) | 2/115 (1.7) | 2/180 (1.1) | .779 |
DNMT3A n/N (%) | 207/1187 (17.4) | 30/115 (26.1) | 59/180 (32.8) | < .001 |
EZH2 n/N (%) | 29/1187 (2.4) | 5/115 (4.3) | 5/180 (2.8) | .472 |
GATA2 n/N (%) | 77/1187 (6.5) | 1/115 (0.9) | 4/180 (2.2) | .005 |
IKZF1 n/N (%) | 19/1187 (1.6) | 2/115 (1.7) | 1/180 (0.6) | .543 |
JAK2 n/N (%) | 10/1187 (0.8) | 0/115 (0) | 2/180 (1.1) | .56 |
KDM6A n/N (%) | 5/1187 (0.4) | 2/115 (1.7) | 0/180 (0) | .089 |
KIT n/N (%) | 54/1187 (4.5) | 3/115 (2.6) | 2/180 (1.1) | .066 |
KRAS n/N (%) | 48/1187 (4) | 1/115 (0.9) | 3/180 (1.7) | .075 |
NRAS n/N (%) | 146/1187 (12.3) | 7/115 (6.1) | 10/180 (5.6) | .006 |
PHF6 n/N (%) | 23/1187 (1.9) | 1/115 (0.9) | 2/180 (1.1) | .553 |
PTPN11 n/N (%) | 53/1187 (4.5) | 6/115 (5.2) | 6/180 (3.3) | .711 |
RAD21 n/N (%) | 37/1187 (3.1) | 0/115 (0) | 4/180 (2.2) | .134 |
RUNX1 n/N (%) | 61/1187 (5.1) | 4/115 (3.5) | 10/180 (5.6) | .702 |
SMC1A n/N (%) | 14/1187 (1.2) | 1/115 (0.9) | 2/180 (0) | .955 |
SMC3 n/N (%) | 8/1187 (0.7) | 2/115 (1.7) | 1/180 (0.6) | .425 |
STAG2 n/N (%) | 34/1187 (2.9) | 5/115 (4.3) | 12/180 (6.7) | .029 |
TET2 n/N (%) | 147/1187 (12.4) | 4/115 (3.5) | 13/180 (7.2) | .003 |
TP53 n/N (%) | 36/1187 (3) | 1/115 (0.9) | 1/180 (0.6) | .072 |
WT1 n/N (%) | 83/1187 (7) | 2/115 (1.7) | 4/180 (2.2) | .006 |
ZRSR2 n/N (%) | 13/1187 (1.1) | 0/115 (0) | 3/180 (1.7) | .399 |
No co-mutation n/N (%) | 42/1187 (3.5) | 1/115 (0.9) | 0/180 (0) | .012 |