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Table 2 Overview of the co-mutational distributions

From: Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation

Mutations

IDHWT

IDH1mut

IDH2mut

p-Value

ASXL1 n/N (%)

46/1187 (3.9)

5/115 (4.3)

14/180 (7.8)

.059

BCOR n/N (%)

30/1187 (2.5)

3/115 (2.6)

8/180 (4.4)

.342

BCORL1 n/N (%)

26/1187 (2.2)

3/115 (2.6)

7/180 (3.9)

.383

CBL n/N (%)

14/1187 (1.2)

2/115 (1.7)

3/180 (1.7)

.779

CEBPA biallelic (%)

136/2129 (6.4)

1/195 (0.5)

3/274 (1.1)

< .001

CSF3R n/N (%)

13/1187 (1.1)

2/115 (1.7)

2/180 (1.1)

.825

CUX1 n/N (%)

22/1187 (1.9)

2/115 (1.7)

2/180 (1.1)

.779

DNMT3A n/N (%)

207/1187 (17.4)

30/115 (26.1)

59/180 (32.8)

< .001

EZH2 n/N (%)

29/1187 (2.4)

5/115 (4.3)

5/180 (2.8)

.472

GATA2 n/N (%)

77/1187 (6.5)

1/115 (0.9)

4/180 (2.2)

.005

IKZF1 n/N (%)

19/1187 (1.6)

2/115 (1.7)

1/180 (0.6)

.543

JAK2 n/N (%)

10/1187 (0.8)

0/115 (0)

2/180 (1.1)

.56

KDM6A n/N (%)

5/1187 (0.4)

2/115 (1.7)

0/180 (0)

.089

KIT n/N (%)

54/1187 (4.5)

3/115 (2.6)

2/180 (1.1)

.066

KRAS n/N (%)

48/1187 (4)

1/115 (0.9)

3/180 (1.7)

.075

NRAS n/N (%)

146/1187 (12.3)

7/115 (6.1)

10/180 (5.6)

.006

PHF6 n/N (%)

23/1187 (1.9)

1/115 (0.9)

2/180 (1.1)

.553

PTPN11 n/N (%)

53/1187 (4.5)

6/115 (5.2)

6/180 (3.3)

.711

RAD21 n/N (%)

37/1187 (3.1)

0/115 (0)

4/180 (2.2)

.134

RUNX1 n/N (%)

61/1187 (5.1)

4/115 (3.5)

10/180 (5.6)

.702

SMC1A n/N (%)

14/1187 (1.2)

1/115 (0.9)

2/180 (0)

.955

SMC3 n/N (%)

8/1187 (0.7)

2/115 (1.7)

1/180 (0.6)

.425

STAG2 n/N (%)

34/1187 (2.9)

5/115 (4.3)

12/180 (6.7)

.029

TET2 n/N (%)

147/1187 (12.4)

4/115 (3.5)

13/180 (7.2)

.003

TP53 n/N (%)

36/1187 (3)

1/115 (0.9)

1/180 (0.6)

.072

WT1 n/N (%)

83/1187 (7)

2/115 (1.7)

4/180 (2.2)

.006

ZRSR2 n/N (%)

13/1187 (1.1)

0/115 (0)

3/180 (1.7)

.399

No co-mutation n/N (%)

42/1187 (3.5)

1/115 (0.9)

0/180 (0)

.012

  1. p-Values indicating parameters that show significant differences are highlighted in bold