Posttranslational control of lipogenesis in the tumor microenvironment

Table 2 Targeting posttranslational modification of cancer lipid metabolism enzymes for cancer treatment

Protein	Targeting PTMs	Drugs	Function	References
HMGCR	De-ubiquitination	GSK2643943A	To de-stabilize HMGCR	[133]
FXR	SUMOylation	SP/GA	To enhance FXR protein levels	[190,191,192]
ME1	Phosphorylation	Ulixertinib	To repress ME1 de-ubiquitination and promote it degradation	[193]
GNPAT	Acetylation	AH	Mediated GNPAT ubiquitination and degradation	[139]
SREBP1	Phosphorylation	Sorafenib	Reduction SREBP1 protein levels	[194]
SREBP1	Phosphorylation	Silibinin	To block SREBP1 nuclear translocation	[195]

ISSN: 1756-8722