Fig. 2

Differences in regional fragmentation between cfDNA from CRC patients and healthy controls. A Heat map showing the z -scored of S/L-ratios in 100 kb bins of each sample compared to healthy controls. B Significant differences in z-scored S/L-ratios between samples collected from CRC patients with clinically diagnosed tumor burden and healthy controls were observed on multiple chromosome arms. (*: p-value ≤ 5*10^–2, **: p-value ≤ 1*10^–2, ***: p-value ≤ 1*10^–3, ****: p-value ≤ 1*10^–4)