Fig. 4

Matched plasma and tumor analysis. To validate the SCNA analysis integrated in LIFE-CNA we performed a matched analysis of plasma samples collected at diagnosis with tumor tissue. A Total SCNAs present in plasma (red) or tumor (blue) only or in both plasma and tumor (yellow) and B focal SCNAs present in plasma (pink) or tumor (violet) only or in both plasma and tumor (green) present on each chromosome for individual patients and summarized over all patients below. Since more than one SCNA can be present per chromosome, it is possible that on the same chromosome different SCNAs are detected in plasma only, tissue only or in both plasma and tumor tissue