Fig. 3

Representative indole alkaloids in clinical and preclinical studies. A Natural indole alkaloids are an important source of lead compounds, and the above chart shows representative natural indole alkaloids that have been used in clinic. B Indole alkaloids and their derivatives regulate tumor cell apoptosis, autophagy, ferroptosis, mitotic catastrophe, necroptosis, and anoikis, through a variety of cellular signaling pathways, which are currently in preclinical studies and are expected to provide promising strategies for cancer therapy