Table 4 Indole alkaloids targeting other RCD subroutines in cancer
Compound | Structure | Source | Target | Mechanism in RCD | Cancer cell line | Tumor type | Refs. |
|---|---|---|---|---|---|---|---|
DM10 |
| Bis-isatin derivative | DJ-1, ROS↑ | Induce ferroptosis | H1299, MDA-MB-231, BEL7402, 786-O | Lung cancer; breast cancer; liver cancer; renal cancer | [255] |
Brucine |
| Strychnos nux-vomica | ATF3, H2O2, TFR↑ System Xc-↓ | Induce ferroptosis | U87 and U251 cells | Glioma | [259] |
3,3′-Diindolylmethane |
| Cruciferous plants | GSH, SLC7A11, GPX4↓ Lipid ROS↑ | Induce ferroptosis | BGC-823 | Gastric cancer | [260] |
Vincristine |
| Catharanthus roseus | CDK1↓ Aurora B, histone-H3, NuMA↑ | Induce mitotic catastrophe | HT-29 and HeLa Cells | Colorectal cancer, cervical cancer | [265] |
BPR0L075 |
| Combretastatin A-4 derivative | Securin, SAC↑ G2/M phase arrest | Induce mitotic catastrophe | HCT116 | Colorectal cancer | [267] |
Cyclin B1, BubR1, MPM-2, survivin↑ | Induce mitotic catastrophe | OVCAR-3-TR and SKOV-3-TR | Ovarian cancer | [269] | |||
Staurosporine |
| Streptomyces staurosporeus | RIPK1, MLKL↑ | Induce necroptosis | U937 cell | Lymphoma | [275] |
10-Methoxycanthin-6-one |
| Canthin-6-one derivative | RIPK3, MLKL↑ | Induce necroptosis | Kasumi-1 cell | Acute myeloid leukemia | [277] |
Diindolylmethane |
| Cruciferous plants | Gli1↓ cleaved PARP, caspase-3↑ | Induce anoikis | A2780 and OVCAR-429 cells | Ovarian cancer | [283] |
K252a |
| Staurosporine derivative | BDNF/TrkB↓ | Induce anoikis | HONE-1-EBV, HK1-LMP1, C666-1 | Nasopharyngeal carcinoma | [284] |
