Table 5 Combination therapy for indole alkaloids to treat cancer

3,10-Dibromofascaplysin

Olaparib (PARP inhibitor)

Induce apoptosis

Prostate cancer

[322]

Cytarabine (DNA synthesis inhibitor)

Induce apoptosis

Myeloid leukemia

[152]

EE-84

A-1210477 (Mcl-1 inhibitor)

Induce apoptosis

Chronic myeloid leukemia

[242]

1-(4-Methoxystyryl)-2-benzyl-9-(3-phenylpropyl)-β-carbolinium bromide

LY294002 (PI3K inhibitor)

Induce apoptosis

Colorectal cancer

[133]

Brucine

Gemcitabine (DNA synthesis inhibitor)

Induce apoptosis

Breast cancer

[323]

Indole-3-carbinol

Hydroxychloroquine (Antimalarial agent)

Induce apoptosis and autophagy

Ehrlich ascites carcinoma

[219]

Indole alkaloid derivative B

5-Fluorouracil (Thymidylate synthase inhibitor)

Induce autophagy

Lung cancer; breast cancer; colonic adenocarcinoma

[325]

Brassinin

Capsaicin (Chilli pepper)

Induce apoptosis

Prostate cancer

[326]

Jerantinine B

δ-Tocotrienol

Induce apoptosis

Glioblastoma, colorectal cancer

[328]

Jerantinine A

γ-Tocotrienol

Induce apoptosis

Brain cancer

[329]

Vincristine

LY294002 (PI3K/Akt inhibitor)

Induce apoptosis

Gastric cancer

[331]

Berberine (Coptidis rhizome)

Induce apoptosis

Hepatocellular carcinoma

[332]

Cotylenin A (plant growth regulator)

Induce apoptosis and autophagy

Multiple myeloma

[333]

Vinblastine

Temsirolimus (mTOR inhibitor)

Induce apoptosis

Hepatocellular carcinoma

[334]

Indibulin (Microtubule inhibitor)

Induce apoptosis

Breast cancer

[335]

Indirubin (Indigo naturalis)

–

Cervical cancer

[336]

Vinorelbine

TRAIL (Apoptosis inducer)

Induce apoptosis

Non-small cell lung cancer

[339]

FGF401 (FGFR-4 inhibitor)

Induce apoptosis

Hepatocellular carcinoma

[342]

Lenvatinib (Tyrosine kinase inhibitor)

Induce apoptosis

Anaplastic thyroid cancer

[343]

Schisandrin B (Schisandra chinensis (Turcz.) Baill.)

Induce apoptosis

Gastric cancer

[345]