Fig. 1
From: Liquid biopsy: current technology and clinical applications
A Types of liquid biopsies. Liquid biopsy is most commonly obtained via blood sampling, but can also be derived from urine, CSF, ascites fluid, and pleural fluid. cfDNA/ctDNA, CTCs, RNA, and extracellular vesicles can be isolated from these fluids. Protein expression and methylation patterns can also be assessed with liquid biopsy. Boxes represent examples of fluids biopsied and circles represent examples of materials isolated/evaluated. B Clinical applications of liquid biopsies. Liquid biopsies (cfDNA/ctDNA and CTCs) have been utilized for a variety of purposes as noted. C Examples of types of liquid biopsies, material isolated/analyzed, and clinical applications. Liquid biopsy is most commonly obtained via blood sampling, but can also be derived from a variety of other fluids. cfDNA/ctDNA and CTCs are the most commonly isolated and analyzed materials. cfDNA: cell-free DNA, ctDNA: circulating tumor DNA, CTCs: circulating tumor cells