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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Fig. 2

Prognostic values of ctDNA mutation. a, b Analysis of recurrence-free survival of patients stratified by 7-day postsurgical (a) and longitudinal (b) ctDNA detection. Univariate Cox regression results were shown. c The results of multivariate-Cox regression for recurrence-free disease in patients stratified by longitudinal ctDNA detection. d Swimmer plot illustrating the ctDNA status, adjuvant therapy, and pathological events of cases with disease recurrence (n = 34). e Time of the earliest ctDNA detection and radiographic relapse, measured by days from the surgery. f Analysis of recurrence-free survival of patients stratified by the clonality of longitudinal ctDNA detection. The ctDNA-positive (Clone) group comprised patients with at least one clonal mutation detected in at least one postsurgical plasma sample. The ctDNA-positive (Subclone) group comprised patients with at least one subclonal mutation detected in at least one postsurgical plasma sample and no clonal mutation detected in any postsurgical samples. The ctDNA-negative group comprised patients with no mutation detected in any postsurgical plasma samples. g, h Clonal phylogenetic information of tissue and plasma samples of Patient 60 (g) and Patient 53 (h). Heatmaps denote mutation profiles of multi-regionally resected primary tumors, lymph node metastasis, and plasma samples with clonal annotation (leftmost column) representing mutation clusters. Phylo-groups comprise samples having identical clonal phylogeny. Colored nodes denote the detection of ctDNA mutations in respective clones, whereas gray nodes denote that no mutation in respective clones was detected

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