Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

Table 1 Small-molecule inhibitors targeting glycolytic metabolism in CRC

Compound	Target	Combined therapy	Outcomes	Reference
BAY-876	GLUT1	NA	Inhibit proliferation	[258]
WZB117	GLUT1	5-Fu	Reduce 5-Fu resistance	[261]
2-DG	HK	5-Fu/Oxaliplatin	Increase chemosensitivity, inhibit migration	[265]
Gossypol	LDHA	5-Fu	Increase chemosensitivity, inhibit tumor growth in vivo and vitro	[270,271,272]
Dichloroacetate	PDK	5-Fu/Oxaliplatin	Increase chemosensitivity, inhibit tumor growth in vivo and vitro	[273,274,275]
AZD3965	MCT1	NA	Inhibit growth and glycolysis	[276]
SLC-0111	CAIX	5-FU	Increase chemosensitivity, inhibit tumor growth	[277, 278]

ISSN: 1756-8722