Fig. 5
From: The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment
Preclinical and clinical trials targeting cell cycle checkpoints and PARP inhibitors (PARPi). The different colors of the blocks represent various cancer tissues, labeled with details. On the left side, the number in each block indicates the number of cell lines treated with the indicated combination. Each block on the right indicates a clinical trial, and the trial phase is indicated with Roman letters. ATRi ATR inhibitors; CHK1i CHK1 inhibitors; WEE1i WEE1 inhibitors; △ATM ATM alterations; △CHK2 CHK2 alterations; △TP53 TP53 alterations