Table 1 B7-H3 in other cancers
From: Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapy
Cancer types | Authors | Year | Type of samples analyzed | Expression | Functions | References |
|---|---|---|---|---|---|---|
Esophageal cancer | Chen et al. | 2015 | Cancer cell line and human esophageal cancer tissues | High B7-H3 expression in 97 out of 174 cancer tissues, correlated with poorer survival and invasion depth | B7-H3 expression inversely correlated with infiltrated T cells | [166] |
Merkel cell carcinoma | Aung et al. | 2019 | MCC cancer tissues | Consistent low expression of B7-H3 in MCC tumor cell, 9/20 strongly expressed in associated endothelial cells | Colocalization of endothelia CD31 expression and B7-H3 expression is a poor prognostic indicator | [167] |
Ovarian cancer | Cai et al. | 2020 | Ovarian cancer xenograft model | B7-H3 robustly expressed in 24 ovarian cancer tissues | B7-H3 inhibits CD8+ T cell function, correlates with T cell exhaustion, which can be reversed by targeting B7-H3 in murine model | [99] |
Acute myeloid leukemia | Lichtman et al. | 2021 | AML cell lines, primary AML blast, normal bone marrow and xenograft models | B7-H3 is highly expressed on monocytic AML cell lines and primary AML blasts from patients | B7-H3 CAR-T showed potent anti-AML effect in vitro and in xenograft model | [168] |
Pancreatic cancer | Si et al. | 2022 | Pancreatic adenocarcinoma tissues | High B7-H3 expression in 52/104 cases, verified in TCGA data | High B7-H3 expression correlates with poor differentiation level, predicts a poor prognosis | [169] |
Urothelial carcinoma | Koyama et al. | 2020 | Urothelial carcinoma tissues | B7-H3 expression was observed in 36 of 271 (13%) cases | B7-H3 expression was significantly associated with shorter PFS, disease-specific survival, tumor stage, grade and lymph node involvement | [170] |
Laryngeal squamous cell cancer | Li et al. | 2021 | LSCC tissues and adjacent tissues | 75/122 (61.5%) stained strongly positive for B7-H3, verified by RNA seq and TCGA data | B7-H3 overexpression significantly correlated with poor OS and lower TIL density | [171] |
Skull base chordoma | Long et al. | 2021 | Chordoma samples and B7-H3 positive cell lines | B7-H3 positively was observed in 7 out of 45 (16%) chordoma samples | B7-H3 CAR-T showed potent anti-chordoma effect in vitro | [172] |