Table 2 Roles of pyroptosis across various pediatric cancers
From: The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy
Cancer types | Design | Experimental design | Cellular process | Cell viability and impact |
|---|---|---|---|---|
Osteosarcoma | Dioscin | In vitro/in vivo | G2/M-phase arrest, apoptosis, and GSDME-dependent pyroptosis | Inhibited cell proliferation |
Clinical control and statistical analysis | Primary clinical samples and normal bone tissues | NA | Poor chemotherapy response, distant metastasis, worse prognosis | |
Neuroblastoma | Dasatinib | In vitro | Pyroptosis | Low cell survival rate |
CPF | In vitro | NLRP3-dependent pyroptosis via miR-181/SIRT1/PGC-1α/Nrf2 pathway | Inhibited cell viability, and proliferation | |
BM-MSCs-Exo | In vitro | OGD-mediated pyroptosis, inhibited GSDMD shuttle from nucleus to cytoplasm | Reduced dead cell ratio | |
Leukemia | Val-boroPro | In vitro/in vivo | Pro-caspase-1-dependent pyroptosis | Reduced cell viability, and increased cell death ratio |
MgSO4 | In vitro | Inhibited ASC oligomerization, NLRP3-dependent pyroptosis | Smaller cell size, lower level of pyroptotic cell death | |
Tp92 | In vitro | Atypical pyroptosis via pro‐caspase‐1 pathway, apoptosis via the RIPK1/caspase‐8/caspase‐3 pathway | Increased cell death ratio | |
CAR-T cells incubated with CD19 + leukemic cells | In vitro/in vivo | GSDME-mediated pyroptosis | Decreased cell viability, CRS controlled | |
Lymphoma | Sesamin | In vivo | Apoptosis, pyroptosis, autophagy | Inhibited growth and proliferation |
BAFF | In vitro | NLRP3-dependent pyroptosis, src activity-dependent ROS production, potassium ion efflux | Decreased cell viability | |
OX40 stimulation | In vivo | Pro-caspase-1-dependent pyroptosis | Decreased cell viability, and liver injury | |
Iridium (III) complexes | In vitro* | Mitochondria-mediated apoptosis, GSDME-mediated pyroptosis | Decreased cell viability | |
Brain tumors | Benzimidazoles | In vitro/in vivo | Cell cycle arrest via P53/P21/cyclin B1, mitochondria-dependent apoptosis, NLRP3-dependent pyroptosis | Inhibited cell proliferation, migration, and invasion |
Galangin | In vitro/in vivo | Apoptosis, pyroptosis and autophagy | Suppressed tumor growth, reduced cell viability and proliferation | |
miRNA-214 | In vitro | Caspase-1-mediated pyroptosis | Inhibited cell proliferation and migration |