Table 3 Compounds inducing pyroptosis signal pathways in cancers
From: The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy
Classification | Compounds | Cancer types | Mechanisms of pyroptosis induction | References |
|---|---|---|---|---|
Chemotherapy drugs | Decitabine/azacitidine | MDS/AML | Caspase-3/GSDME | |
Dasatinib | Neuroblastoma/Lung cancer | Caspase-3/GSDME | [38] | |
PTX/cisplatin | Lung cancer | Caspase-3/GSDME | [64] | |
DOX, Actinomycin-D, Bleomycin, Topotecan | Lung cancer | Caspase-3/GSDME | [62] | |
Lobaplatin | Colon cancer | ROS/JNK/caspase-3/GSDME | [65] | |
DOX | Melanoma | eEF-2K/caspase-3/ GSDME | [66] | |
Natural products | Dioscin | Osteosarcoma | Caspase-3/GSDME | [33] |
Galangin | Brain tumors | GSDME | [67] | |
Anthocyanin | OSCC | NLRP3/caspase-1/GSDMD | [68] | |
Sesamin | Lymphoma | NLRP3/caspase-1 | [69] | |
Reagents | Iridium (III) complexes | Several cancers* | Caspase-3/GSDME | [70] |
miRNA-214 | Brain tumors | Caspase-1 | [71] | |
GSDMD-N packaged in rAAVs | Brain tumors | GSDMD | [72] | |
BRAFi/MEKi | Melanoma | GSDME/ HMGB1 | [73] |