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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: FIT-based risk-stratification model effectively screens colorectal neoplasia and early-onset colorectal cancer in Chinese population: a nationwide multicenter prospective study

Fig. 2

A–B Risk-stratification based comparisons of CN, ACN, and CRC prevalence between derivation and validation cohort or between NSGS and asymptomatic cohort. & Low risk represents participants with FIT- and low-risk score, and high risk represents participants with FIT+ or intermediate/high-risk score; * P value for intermediate risk vs. low risk; # P value for high risk vs. low risk. C–E Comparison of AUCs for CN, ACN, and CRC between the NCPC score and selected risk models or FIT for overall cohort. F Performance of NCPC score or risk-stratification model guided colonoscopy and estimated reduction of colonoscopy burden. & Low risk represents participants with FIT- and low-risk score, and high risk represents participants with FIT + or intermediate/high-risk score; reduction of NNS = (NNS by primary colonoscopy – NNS by NCPC (+FIT)-based algorithm)/(NNS by primary colonoscopy). AUC, area under the receiver operating characteristic curve; CN, colorectal neoplasia; CI, confidence interval; ACN, advanced colorectal neoplasia; CRC, colorectal cancer; NCPC, National Colorectal Polyp Care; BMI, body mass index; FDR, first-degree relative; PNC, previous negative colonoscopy; APCS, Asia–Pacific Colorectal Screening score; FIT, fecal immunochemical test; RR, relative risk. NNS, number needed for screening colonoscopy to detect one lesion; and ROC, receiver operating characteristic

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