Fig. 5
From: JMJD4-demethylated RIG-I prevents hepatic steatosis and carcinogenesis
Hepatocyte-specific RIG-I deficiency abolishes steatosis, and the following NASH, and NASH-induced hepatocarcinogenesis. a Tumor incidence (chi-square test), number and maximum diameter (unpaired t-test) of STAM HCC in male Rig-If/f and Rig-Ihep−/− mice were analyzed (n = 12). b Representative livers of STAM HCC in male Rig-If/f and Rig-Ihep−/− mice. c, d HE (c) and oil red O (d) staining were analyzed in nontumor liver tissues of STAM model in male Rig-If/f and Rig-Ihep−/− mice. Scale bars: 20 μm. e, f HE (e) and oil red O (f) staining were analyzed in liver tissues of MCD model in male Rig-If/f and Rig-Ihep−/− mice. Scale bars: 20 μm. g, h HE (g) and oil red O (h) staining were analyzed in liver tissues of HFD model in male Rig-If/f and Rig-Ihep−/− mice. Scale bars: 20 μm. i, j Hepatic TG and TC (i), and serum TG and TC (j) were examined in HFD-treated male Rig-If/f and Rig-Ihep−/− mice (n = 4, unpaired t-test). Data are shown as mean ± s.d. or photographs from one representative of three independent experiments. *P < 0.05, **P < 0.01, ▲P > 0.05