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Table 3 Salient toxicities in patients receiving 2 cycles

From: Phase 1 study of intraventricular 131I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies

Dose level (MBq)

N

Fever

Vomiting

Headache

ALT

Bilirubin

AST

Platelets

ANC

Grade

 

2

1

2

2

1

2

3

1

1

2

3

1

2

3

4

1

2

3

4

370

1

                   

740

3

       

1

      

1

    

1110

4

1

 

1

           

2

   

2

1480

2

  

1

1

          

1

   

1

1850

3

  

1

1

    

1

    

1

1

  

1

1

2220

1

   

1

 

1

             

2590

2

     

1

 

1

           

2960

1

  

1

  

1

        

2

   

2

Total

17

1

0

4

3

0

3

0

2

1

0

0

0

0

1

7

0

0

1

6

  1. AST aspartate aminotransferase, ANC absolute neutrophil count,
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Journal of Hematology & Oncology

ISSN: 1756-8722

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