Fig. 1

Multi-omics landscape of PDAC Samples. A Overview of the experimental design and the number of samples for the genomic, transcriptomic, proteomic, and phosphoproteomic analyses. B The genomic profiles of PDAC. The top 20 mutated genes and their occurrence in 149 PDAC patients and the mutation frequencies are shown. Mutation types and their frequencies are demonstrated by a bar plot in the right panel. C Spearman’s correlation plot indicating the mutation frequencies observed in the Fudan cohort compared to previously published cohorts. D Comparisons of mutation frequencies of top 10 mutated genes in the Fudan cohort and previously published cohorts. E Bar plots of the common KRAS driver mutations in Fudan cohort and previously published cohorts. ****p < 1.0E−4, ***p < 1.0E−3, **p < 1.0E−2, *p < 0.05, ns > 0.05