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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma

Fig. 4

The effects of diabetes on the proteogenomic characteristics of PDAC. A Heatmap illustrating genomic alternations, biological pathways and protein abundance involved in these pathways of patients with and without diabetes. B Boxplots indicating GSVA score of insulin signaling pathway (left) and mTOR signaling pathway (right) between patients with and without diabetes (Wilcoxon test). C The pie charts indicating the percentage of patients with 10q25.3 deletion or MTOR mutations in patients with and without diabetes (left). Heatmap illustrates the association among MTOR mutations, 10q25.3 deletion and diabetes (Fisher’s exact test). D The heatmap indicating the cis-effect of AFAP1L2 at chromosome locus 10q25.3 (Spearman’s correlation). E The scatter plot depicting the correlation between AFAP1L2 expression and KEGG pathways (GSVA score) (Spearman’s correlation). F Spearman-rank correlation of the abundance of AFAP1L2 and phosphatidylinositol signaling system (GSVA score). G The scatter plot depicting the correlation between abundance of AFAP1L2 and proteins involved in phosphatidylinositol signaling system (Spearman’s correlation). H Spearman-rank correlation of the abundance of AFAP1L2 and AKT1/2. I Heatmap indicating the impacts of AKT1 abundance on proteins involved in mTOR signaling pathway (upper). The lower heatmap indicates the impacts of activity of AKT1 on abundance of the phosphosites involved in mTOR signaling pathway. J Heatmap indicating the impacts of MTOR mutations on MTOR RNA, MTOR protein expression, kinase activity and phosphosites. K Bar plots indicating biological pathways downregulated in patients with MTOR mutations on proteomic level (left) and phosphoproteomic level (right). L Phosphosubstrates of MTOR differentially expressed between MTOR-mutant patients and MTOR wild-type patients. Significantly downregulated phosphosubstrates are highlighted in blue, and remaining sites are in gray. M The scatter plot depicting the correlation between abundance of EIF4EBP1_pT37 and all identified proteins (Spearman’s correlation). Proteins involved in mTOR signaling pathway are highlighted in red. N Bubble plots indicating biological pathways that EIF4EBP1_pT37 significantly positively correlated proteins enriched in. O The pathway (middle) and expression (down) heatmap depicting the pathways and pathway related proteins positively correlated with the EIF4EBP1_pT37 expression (Spearman’s correlation). P Heatmap indicating four mTOR-signaling-pathway-related proteins positively correlated with MGPS score (Spearman’s correlation). Q The systematic diagram summarizing the impacts of MTOR mutations and 10q25.3 deletion on mTOR signaling pathway and cell proliferation. ****p < 1.0E−4, ***p < 1.0E−3, **p < 1.0E−2, *p < 0.05, ns > 0.05

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