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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance

Fig. 3

The procedures after osimertinib resistance. Before osimertinib treatment, patients should be examined via tissue biopsy and/or liquid biopsy to confirm whether EGFR mutations exist. Liquid biopsy can be used as a noninvasive and practical method for dynamic monitoring to evaluate genomic status in the period of osimertinib treatment. When patients progress on osimertinib, tissue biopsy and/or liquid biopsy should be conducted to determine the mechanisms of resistance to osimertinib to guide treatment. A corresponding treatment regimen will be applied to treat patients if effective approaches currently exist; in the case of a lack of valid targets, preclinical studies and clinical trials are warranted to be taken into consideration for the acquisition of valuable evidence to further explore viable therapeutic strategies

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