Fig. 1From: Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis researchDetailed mechanism of necroptosis. Necroptosis is initiated by the cell surface death receptors (including FasRs, TNFR, IFN receptors, and TLRs) and ZBP1 in cells, and downstream proteins which contain RHIM bind to RIPK3. Subsequently, the necrosome is formed and led to cell lysisBack to article page