Fig. 4From: Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis researchAn excess Cu(II) supply can lead to cell pyroptosis (By BioRender). The uptake of Cu(II) into cells triggers pyroptosis via protein lipoylation, which is an important mechanism for the enzymatic function of proteins in the TCA (tricarboxylic acid) cycleBack to article page