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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: The development of a cSMART-based integrated model for hepatocellular carcinoma diagnosis

Fig. 1

Combined method holds a strong value in diagnosis of HCC. a Basic information (age, gender), cirrhosis background, tumor serological biomarkers (CA199, PIVKA-II, AFP-L3, AFP), and HCC related parameters (MVI and BCLC stages) of all HCC samples with positive mutations at the top 20 high-frequency mutation sites. CA199: carbohydrate antigen199; MVI: microvascular invasion; and BCLC: Barcelona clinic liver cancer. b ROC curves of Combined method and AFP for HCC patients versus LC patients in the training, test, and validation cohorts. c Proportions of positive and negative calling by Combined method, GALAD, and AFP in all participants with different AFP, AFP-L3, and PIVKA-II levels in test cohort. d Proportions of positive and negative calling by Combined method, GALAD, and AFP in all participants with different age, gender, Child–Pugh stages, HBV infection status, and cirrhosis history in test cohort. e Proportions of positive and negative calling by Combined method, GALAD, and AFP in HCC patients with different tumor sizes and BCLC stages in test cohort

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