Fig. 2
From: Protein degradation: expanding the toolbox to restrain cancer drug resistance
Protein degradation regulates drug efflux. ABCC1, ABCB1, and ABCG2 are the three main drug transporters. NEDDL ligases the ubiquitin chain to ABCC1, while USP22 and USP24 eliminate the ubiquitin chain. CUL3 regulates ABCC1 expression by modulating the degradation of NRF2. MARCH8, FBXO15, and FBXO21 ligase the ubiquitin chain on ABCB1, and USP24 acts as the DUB. USP24 is the DUB of ABCG2. RNF180 and UCHL3 indirectly regulate the expression of ABCG2