Fig. 6
From: Protein degradation: expanding the toolbox to restrain cancer drug resistance
Protein degradation involved in EMT and cell stemness. Degradation of E-cadherin is regulated by E3 ligases RNF25, RNF43, and Hakai. Protein degradation of mesenchymal marker ZEB1 is mediated by E3 ligase SIAH1 and can be reversed by USP51. Snail is ubiquitinated by FBXO32 and deubiquitinated by USP1. For stemness sustaining pathways, β-TrCP participates in the ubiquitination of both YAP and β-catenin. In addition, STUB1 also facilitates the ubiquitination of YAP. USP10 facilitates deubiquitylation of YAP, and USP20, USP4, and USP22 deubiquitinate β-catenin