Table 2 Acute and long-term toxicities after ET019003 treatment
From: Novel CD19-specific γ/δ TCR-T cells in relapsed or refractory diffuse large B-cell lymphoma
Patient ID | Dosage of infused TCR + T cells | CRS (duration) | ICANS (duration) | Treatment for CRS/ICANS | Hematologic AEs (duration) | Related to FC | Other AEs |
|---|---|---|---|---|---|---|---|
1 | 2 × l06/kg | No | No | No | Grade 4 WBC count decreased (d0–dl4) Grade 4 neutrophil count decreased (d0–dl4) | Yes | Viral encephalitis (ml 8) MOG + encephalomyelitis (m30) |
2* | 1st: 2 × l06/kg | Grade 1 (d2–d8) | Grade 3 (d9–dl4) | Dexamethasone 30 mg | Grade 4 WBC count decreased (dl2–dl9) Grade 4 neutrophil count decreased (d9–dl9) Grade 4 platelet count decreased (dl5-NR) | No | Grade 1 ALT increased (dl3) Grade 2 AST increased (dl3) Grade 1 total bilirubin increased (d28) Grade 1 direct bilirubin increased (d28) Grade 2 hypoalbuminemia (d4-dl 3) |
2nd: 2 × l06/kg | No | No | No | Grade 4 WBC count decreased (d0-NR) Grade 4 neutrophil count decreased (d0-NR) Grade 4 platelet count decreased (d0-NR) Grade 3 anemia (d0-NR) | Yes | Grade 1 total bilirubin increased (d29) Grade 1 direct bilirubin increased (d4-d7, d21-d30) Grade 1 ALT increased (d29–d30) Grade 2 AST increased (d29) Grade 2 hypoalbuminemia (d0–dl6) | |
3 | 2 × l06/kg | Grade 1 (d9) | No | No | Grade 3 neutrophil count decreased (d10–d13) | No | Grade 2 ALT increased (m2–m3) Grade 1 AST increased (dl5–m3) Grade 1 ALP increased (m6) |
4 | 2 × l06/kg | No | No | No | Grade 2 neutrophil count decreased Grade 1 total bilirubin increased (d18) | No | Grade 4 intestine perforation (d16) Grade 1 total bilirubin increased (m6) Grade 1 ALT increased (m6–m9) Grade 1 AST increased (m6–m9) Grade 2 hypoalbuminemia (d17–d18) |
5 | 1st: 2 × l06/kg | No | No | No | Grade 3 WBC count decreased (d1–d4) Grade 3 neutrophil count decreased (d4–d8) Grade 3 platelet count decreased (d23–d24) | Yes | Grade 1 total bilirubin increased (m9, ml8, m24) Grade 1 direct bilirubin increased (m9, m18, m24) Grade 2 hypoalbuminemia (d0–d6) |
2nd: 2 × l06/kg | No | No | No | Grade 3 WBC count decreased (d10–d22) Grade 4 neutrophil count decreased (d10–d22) Grade 3 platelet count decreased (d3–1d10) | No | Grade 1 total bilirubin increased (d10–d20) Grade 1 direct bilirubin increased (d8–15) | |
6 | 2 × l06/kg | No | No | No | Grade 4 WBC count decreased (d1–d25) Grade 4 neutrophil count decreased (d1–d24) Grade 2 platelet count decreased | Yes | No |
7 | 1st: 4 × l06/kg | Grade 1 (d2) | No | No | Grade 4 WBC count decreased (d0–d10) Grade 4 neutrophil count decreased (d0–d12) Grade 1 anemia | Yes | Grade 1 total bilirubin increased (m6) Grade 1 direct bilirubin increased (m6) |
2nd: 4 × l06/kg | No | No | No | No | NA | No | |
8 | 4 × l06/kg | No | No | No | Grade 3 WBC count decreased (d0–d14) Grade 3 neutrophil count decreased (d2–d14) Grade 1 platelet count decreased | Yes | Grade 3 pulmonary infection (d15–d18) |