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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Plasma extracellular vesicle messenger RNA profiling identifies prognostic EV signature for non-invasive risk stratification for survival prediction of patients with pancreatic ductal adenocarcinoma

Fig. 3

Prognostic EV mRNA signature establishment and validation in PDAC patients. A The prognostic correlation of plasma EV total RNA concentration from patients in the training cohort were assessed by Kaplan–Meier survival analysis. B Kaplan–Meier survival curves for the candidate EV mRNA expression levels of the patients in the training cohort. The expression data were obtained from the digital droplet polymerase chain reaction (ddPCR) analysis. MPP4: Membrane Palmitoylated Protein 4; PPP1R12A: Protein Phosphatase 1 Regulatory Subunit 12A; SCN7A: Sodium Voltage-Gated Channel Alpha Subunit 7; SGCD: Sarcoglycan Delta. C-D The prognostic performance of EV mRNA signature consisted of PPP1R12A, SCN7A, and SGCD in the training and validation cohort were assessed by Kaplan–Meier survival analysis. Hazard ratio (HR) and 95% confidence interval (CI) were generated from univariate Cox proportional hazard regression analysis. Statistical differences were analyzed with log-rank test. p < 0.05 is considered statistically significant

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Journal of Hematology & Oncology

ISSN: 1756-8722

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