Fig. 1
From: Exploiting RIG-I-like receptor pathway for cancer immunotherapy
Schematic illustration of the domains of RLRs. a Both RIG-I and MDA5 have two N-terminal tandem caspase activation and recruitment domains (CARDs), two central Rec A domains (Hel‐1 and Hel‐2), and a C-terminal domain (CTD), while LGP2 is lack of CARD. b Under resting states, the CARDs of RIG-I are masked by an autoinhibitory conformation. The binding of 5′-ppp dsRNA to RIG-I triggers the unmasking of CARDs that allows signal transmission