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Table 1 Properties of CAR T cells targeting T cell malignancies

From: CAR T cell therapy for T cell leukemia and lymphoma: latest updates from 2022 ASH Annual Meeting

Product

Genome editing

PEBL

Target

T cells

References

BE-CAR7

+

–

CD7

Off-the-shelf

[4]

RD-13-01

+

–

CD7

Off-the-shelf

[5]

PCART7

–

+ CD7

CD7

Donor

[6]

CD3PEBL

–

+ CD3

CD3

Off-the-shelf

[8]

CD3/7PEBL

–

+ CD3/7

CD7

Off-the-shelf

[7]

  1. PEBL protein expression blocker
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Journal of Hematology & Oncology

ISSN: 1756-8722

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