Fig. 10
From: Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
ITGB4 has prognostic relevance and inversely correlates with the number of tumor-associated CD45+ leukocytes in patients. Representative ITGB4 and corresponding GAPDH Western blot bands in ovarian cancer (OvCa) tissue samples. Overall survival of ITGB4Lo (75%) vs. ITGB4Hi (25%) R0-resected serous ovarian cancer patients (A). Representative anti-CD45 and anti-ITGB4 immunostaining images from consecutive intraperitoneal (IP) carcinosis and malignant ascites ovarian cancer patient samples and calculation of the association between both parameters (B). Representative anti-ITGB4 and anti-CD45 immunostaining images from primary and metastatic prostate cancer specimens, ITGB4 levels in different types of prostate cancer samples and association between ITGB4 and number of tumor-associated leukocytes in these samples except lymph node metastases (LNM) (C). TURp = palliative transurethral resection