Fig. 6
From: Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
ITGB4 depletion requires E- and P-selectin double knockout for synergistic tumor growth reduction and is accompanied by increased leukocyte infiltration. Mouse survival after s. c. injection of PC-3 control vs. ITGB4 knockdown cells into E-/P-selectin wildtype, single or double knockout mice (endpoint: xenograft tumor size ~ 1.5 cm3) (A). Representative anti-mCD45 immunostaining images of initial tumor nodules on day 4 after s. c. injection of PC-3 or PaCa5061 control or ITGB4 KD cells into E-/P-selectin wildtype or double knockout mice (B)