Fig. 3From: APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potentialTwo-factor model for APOBEC3-mediated mutagenesis. In a two-factor model, APOBEC3-mediated mutagenesis needs both induction of APOBEC3 expression and availability of ssDNA. Factors such as drug exposure, telomere crisis, and DNA repair processes can generate ssDNA, while transcriptional triggers can upregulate APOBEC3 expression [94,95,96]Back to article page