Table 2 The role of SASP in tumor microenvironment
| Â | Cancer type | Senescent cell | Senescence inducer | Major roles of SASP | SASP factors |
|---|---|---|---|---|---|
Protumorigenic SASP | hepatocyte | hepatocyte | OIS (N-Ras) | (1) myeloid cell recruitment; (2) MDSC differentiation | CCL2 |
hepatocyte | hepatic stellate cell | HFD | antitumor immunity of CD8+ T cells impairment | PGE2 | |
lymphocyte | lymphocyte | TIS (doxorubicin) | stemness induction | not reported | |
mammary epithelial cell | mammary epithelial cell | TIS (doxorubicin) | mitogenic support | Eotaxin, CXCL5, Rantes | |
mammary epithelial cell | fibroblast | DNA damage (bleomycin) | cancer invasion promotion | MMPs | |
mammary epithelial cell | mammary epithelial cell | OIS (HER2) | cancer metastasis promotion | not reported | |
melanocyte | fibroblast | TIS (CDK4/6 inhibitor) | myeloid cell recruitment | not reported | |
mesothelial cell | mesothelial cell | TIS (pemetrexed) | (1) EMT induction; (2) chemoresistance | not reported | |
prostate epithelial cell | prostate epithelial cell | TIS (PTEN loss) | myeloid cell recruitment | CXCL1, CXCL2 | |
prostate epithelial cell | prostate epithelial cell | TIS (PTEN loss) | MDSC recruitment | not reported | |
thyroid follicular cell | thyroid follicular cell | OIS (BRAF) | anoikis resistance | CXCL12 | |
Antitumorigenic SASP | hepatocyte | hepatocyte | OIS (N-Ras) | immune-related senescent cell clearance | IL-1α |
lymphocyte | lymphocyte | TIS (cyclophosphamide) | cellular senescence reinforcement | not reported | |
melanocyte | melanocyte | TIS (AURKA or CDK4/6 inhibitor) | lymphocyte recruitment | CCL5 | |
melanocyte | melanocyte | TIS (Aurora inhibitor) | cellular senescence reinforcement | not reported | |
osteoblast | osteoblast | TIS (radiotherapy) | NKT cell recruitment | IL-6 | |
pancreatic ductal cell | pancreatic ductal cell | TIS (MEK and CDK4/6 inhibitors) | (1) vascularization promotion (2) drug delivery improvement (3) endothelial cell activation (4) CD8+ T-cell accumulation | VEGF, CCL5, CXCL1, IL-6 | |
hepatocyte | hepatocyte | OIS (N-Ras) | (1) myeloid cell recruitment (2) macrophage differentiation | CCL2 |