Table 1 CTC detection in PDX models
From: The functional and clinical roles of liquid biopsy in patient-derived models
Tumor type | Mice | No. of pdx lines | Metastasis | CTC DR | Method | References |
|---|---|---|---|---|---|---|
Metastatic TNBC | NOD/SCID | 2 | 100% | 100% | Flow cytometry | [17] |
Metastatic and non-metastatic | NOD/SCID | 5 | 10/18 | N/A | N/A | [18] |
Metastatic and non-metastatic BC | SCID/beige or NSG | 18 | 50 | 83% | Anti-human pan-CK IHC | [19] |
NA | SCID | 7 | 0 | 2/7 | EpCAM-based platform | [20] |
Metastatic TNBC | NOD/SCID | 3 | 70 | 11/72 | FACS-based assay | [21] |
BC | SCID | 1 | NA | 2/7 | RT-qPCR | [22] |
TNBC | NSG | 7 | 23/57 | 32/37 | Microfluidic chip | [23] |
TNBC | NSG | 3 | 13/17 | 22/23 | Label-free platform based on physical characteristics | [24] |