From: The functional and clinical roles of liquid biopsy in patient-derived models
Tumor type | Model | Mice | Sample | Isolation | Analysis | Application | References |
---|---|---|---|---|---|---|---|
GB | PDX | rnu/rnu athymic nude rats | Plasma, cerebrospinal fluid and urine | QIAamp circulating nucleic acids kit | dPCR Shallow WGS | Early screening and diagnosis | [76] |
Ewing sarcoma | PDX | NSG mice | Plasma | Qiagen circulating nucleic acid kit | ddPCR | Early screening and diagnosis | [80] |
CTCL | PDX | NSG mice | Plasma | NucleoSpin plasma kit | qPCR | Drug testing | [79] |
CTCL | PDX | NSG mice | Plasma | NucleoSpin Plasma XS kit | qPCR | Drug testing; Tumor burden monitor | [81] |
pRCC | PDX | RAG2−/−γC−/−mice | Plasma | QIAamp DSP virus spin kit | qPCR | Drug testing | [85] |
HGSC | PDX | NOD mice | Plasma | Qiagen investigator kit | Shallow WGS | Tumor burden and response monitor | [86] |
Pancreatic cancer | PDO | N/A | Supernatant | QIAamp ultrasens virus kit | ddPCR NGS | Molecular profiling and drug testing | [84] |
BC | PDX | SCID/Beige mice | Plasma and serum | Quick-cfDNA Serum & Plasma Kit | qRT-PCR | Novel PDX model evaluation | [87] |