Table 3 Role of Notch signaling in regulating the tumor microenvironment
From: The Notch signaling pathway: a potential target for cancer immunotherapy
Regulators | Cancer type | Up/down-regulated | Cell type | Function | References |
|---|---|---|---|---|---|
Jagged1 | BC | Up | Tumor cell | Positively correlated with M2-TAMs infiltration | |
Jagged1 | TNBC | Up | Tumor cell | Positively correlated with TAMs infiltration; Negatively correlated with T cell cytotoxicity activity | [134] |
Jagged1 | PDAC | Up | Tumor cell | Positively correlated with CD68+ macrophages infiltration | [135] |
Dll1 | BC | Unknown | Tumor cell | Positively correlated with accumulation of CD8+T cells and the polarization of M1-TAMs | [136] |
Dll3 | BC | Up | Tumor cell | Positively correlated with Treg cell infiltration | [137] |
Jagged2 | EOC | Up | Tumor cell | Positively correlated with tumor-associated neutrophils; Negatively correlated with CD8+T cell infiltration | [138] |
Notch1; Notch2; Notch4 | BC | Down | Tumor cell | Negatively correlated with Treg cells infiltration | [139] |
Notch1 | Melanoma | Unknown | Tumor cell | Negatively correlated with CD8+ T cells and NK cells infiltration; Positively correlated with MDSCs and Treg cells infiltration | [140] |
Notch1 | TNBC | Unknown | Tumor cell | Positively correlated with CD206+ TAMs and Treg cells infiltration; Negatively correlated with the infiltration of CD8+ T cells | [141] |
Notch1 | HNSCC | Up | Tumor cell | Negatively correlated with MDSCs, TAMs, Treg cells infiltration and the expression of immune checkpoint molecules (e.g., PD-1, CTLA-4, TIM-3, and LAG-3) | [19] |
Notch1; Notch2; RBP-J; Hey1 | Glioma | Down | Tumor cell | Positively correlated with the recruitment of anti-tumor immune cell populations, such as CD8+T cells; Negatively correlated with the recruitment of microglia and TAMs | [142] |
Notch1; Notch2 | GC | Up | Tumor cell | Positively correlated with Treg cells and Th17 cells infiltration | [143] |
Notch3 | GC | Up | Tumor cell | Positively correlated with Treg cell and M2-TAM infiltration and the expression of immune checkpoints (CD276, ADORA2A); Negatively correlated with activated CD8+ T cell infiltration | [144] |
Notch | DLBCL | Up | Tumor cell | Positively correlated with M2-TAMs polarization and infiltration | [146] |
Notch1 | CRC | Up | Epithelial cell | Positively correlated with recruitment of TGF-β-dependent neutrophils | [147] |