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Fig. 7 | Journal of Hematology & Oncology

Fig. 7

From: Myeloid-like tumor hybrid cells in bone marrow promote progression of prostate cancer bone metastasis

Fig. 7

Tumor hybrid cells show an enhanced EMT pathway with higher tumorigenic potential in vivo. a Bar plot showing the result of GSEA of hallmark pathways in tumor cells in hybrid cell-derived tumors. b Violin plots showing the expression of EMT marker genes in tumor cells from RM1-derived tumors and hybrid cell-derived tumors. c GSEA of EMT pathways in hybrid tumor cells compared to RM1 cells. d Tumor-initiating capacity of parental RM1 cells and hybrid tumor cells. e Heatmap showing the differentially expressed genes or proteins in the EMT pathway between RM1 cells and hybrid tumor cells. f Tumor growth curves and tumor formation rate of mice injected subcutaneously with different numbers of tumor cells (n = 10). *P < 0.05, **P < 0.01, ***P < 0.001

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