Table 2 Best overall response
Parameter | N (%) | P | ||
|---|---|---|---|---|
Overall (n = 110) | Before amendment (n = 67) | After amendment (n = 43) | ||
Morphologic response | ||||
CR | 69 (63) | 40 (60) | 29 (67) | 0.41 |
CRp | 19 (17) | 10 (15) | 9 (21) | 0.42 |
CRi | 3 (3) | 1 (1) | 2 (5) | 0.32 |
ORR | 91 (83) | 51 (76) | 40 (93) | 0.02 |
MRD negativity | ||||
At response | 47/87 (54) | 28/49 (57) | 19/38 (50) | 0.51 |
Overall | 75/89 (84) | 41/50 (82) | 34/39 (87) | 0.51 |
No response | 12 (11) | 9 (13) | 3 (7) | 0.29 |
Early death | 7 (6) | 7 (10) | 0 | 0.03 |
MRD negativity | ||||
Salvage 1 | ||||
At response | 41/70 (59) | 23/33 (70) | 18/37 (49) | 0.08 |
Overall | 65/73 (89) | 31/34 (91) | 34/39 (87) | 0.59 |
≥ Salvage 2 | ||||
At response | 6/17 (35) | 5/16 (31) | 1/1 (100) | 0.17 |
Overall | 12/18 (67) | 10/16 (63) | 2/2 (100) | 0.29 |