| All patient (n = 468) | NSCLC (n = 121) | NPC (n = 110) | CC (n = 55) | CRC (n = 27) | SCLC (n = 26) | HCC (n = 25) | Biliary tract carcinoma(n = 21) | Breast cancer (n = 19) | Kidney cancer (n = 18) | Ovarian cancer (n = 8) | Melanoma (n = 6) | Neuroendocrine tumor (n = 6) | Esophageal cancer (n = 5) | Gastric cancer (n = 3) | Others (n = 18) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CR | 1 (0.2) | 0 | 0 | 1 (1.8) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PR | 78 (16.7) | 17 (14.0) | 27 (24.5) | 14 (25.5) | 2 (7.4) | 6 (23.1) | 0 | 0 | 1 (5.3) | 5 (27.8) | 1 (12.5) | 2 (33.3) | 2 (33.3) | 0 | 0 | 1 (5.6) |
SD | 129 (27.6) | 37 (30.6) | 27 (24.5) | 14 (25.5) | 5 (18.5) | 3 (11.5) | 10 (40.0) | 9 (42.9) | 4 (21.1) | 8 (44.4) | 3 (37.5) | 1 (16.7) | 2 (33.3) | 2 (40.0) | 0 | 4 (22.2) |
PD | 213 (45.5) | 52 (43.0) | 52 (47.3) | 18 (32.7) | 18 (66.7) | 11 (42.3) | 15 (60.0) | 12 (57.1) | 12 (63.2) | 4 (22.2) | 3 (37.5) | 1 (16.7) | 1 (16.7) | 2 (40.0) | 3 (100) | 9 (50.0) |
NE | 2 (0.4) | 0 | 0 | 1 (1.8) | 1 (3.7) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
ND | 45 (9.6) | 15 (12.4) | 4 (3.6) | 7 (12.7) | 1 (3.7) | 6 (23.1) | 0 | 0 | 2 (10.5) | 1 (5.6) | 1 (12.5) | 2 (33.3) | 1 (16.7) | 1 (20.0) | 0 | 4 (22.2) |
Confirmed ORR, n (%, 95% CI) | 79 (16.9, 13.6–20.6) | 17 (14.0, 8.4–21.5) | 27 (24.5, 16.8–33.7) | 15 (27.3, 16.1–41.0) | 2 (7.4, 0.9–24.3) | 6 (23.1, 9.0–43.6) | 0 | 0 | 1 (5.3, 0.1–26.1) | 5 (27.8, 9.7–53.5) | 1 (12.5, 0.3–52.7 | 2 (33.3, 4.3–77.7) | 2 (33.3, 4.3–77.7) | 0 | 0 | 1 (5.6, 0.1–27.3) |
DCR, n (%, 95% CI) | 208 (44.4, 39.9–49.1) | 54 (44.6, 35.6–53.9) | 54 (49.1, 39.4–58.8) | 29 (52.7, 38.8–66.3) | 7 (25.9, 11.1–46.3) | 9 (34.6, 17.2–55.7) | 10 (40.0, 21.1–61.3) | 9 (42.9, 21.9–66.0) | 5 (26.3, 9.1–51.2) | 13 (72.2, 46.5–90.3) | 4 (50, 15.7–84.3) | 3 (50.0, 11.8–88.2) | 4 (66.7, 22.3–95.7) | 2 (40.0, 5.3–85.3) | 0 | 5 (27.8, 9.7–53.4) |
Number of DoR events (%) | 20 (25.3) | 5 (29.4) | 9 (33.3) | 2 (13.3) | 1 (50.0) | 1 (16.7) | / | / | 1 (100) | 0 | / | 1 (50.0) | 0 | / | / | 0 |
DoR, m (95% CI) | 11.7 (8.3, –) |  − (4.7, –) | 11.7 (7.7, –) |  − (–, –) |  − (2.9, –) |  − (4.2, –) | / | / | / |  − (–, –) | / |  − (5.4, –) |  − (–, –) | / | / | / |