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  1. Content type: Review

    Advances in the treatment of chronic lymphocytic leukemia (CLL) have improved initial overall response (OR) rates, complete response (CR) rates and progression free survival (PFS). Despite these advances, CLL ...

    Authors: Kami J Maddocks and Thomas S Lin

    Citation: Journal of Hematology & Oncology 2009 2:29

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  2. Content type: Short report

    RIZ1 expression and activity are reduced in many cancers. In AML cell lines and patient material, RIZ1 expression is reduced relative to normal bone marrow. In chronic myelogenous leukemia (CML), blastic trans...

    Authors: Ashakumary Lakshmikuttyamma, Naoto Takahashi, Elodie Pastural, Emina Torlakovic, Hesham M Amin, Guillermo Garcia-Manero, Michael Voralia, Magdalena Czader, John F DeCoteau and C Ronald Geyer

    Citation: Journal of Hematology & Oncology 2009 2:28

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  3. Content type: Case report

    Rheumatoid arthritis (RA) is an autoimmune disease mediated by inflammatory processes mainly at the joints. Recently, awareness of Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder (T-LPD...

    Authors: Michihide Tokuhira, Kyoko Hanzawa, Reiko Watanabe, Yasunobu Sekiguchi, Tomoe Nemoto, Yasuo Toyozumi, Jun-ichi Tamaru, Shinji Itoyama, Katsuya Suzuki, Hideto Kameda, Shigehisa Mori and Masahiro Kizaki

    Citation: Journal of Hematology & Oncology 2009 2:27

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  4. Content type: Case report

    Patients suffering from adult acute lymphoblastic leukemia are acutely ill and present most commonly with fever, pallor, bleeding, lymphadenopathy, hepatosplenomegaly and presence of lymphoblasts in the periph...

    Authors: Farhat Abbas Bhatti, Iftikhar Hussain and Muhammad Zafar Ali

    Citation: Journal of Hematology & Oncology 2009 2:26

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  5. Content type: Review

    Non-prescriptional use of medicinal herbs among cancer patients is common around the world. The alleged anti-cancer effects of most herbal extracts are mainly based on studies derived from in vitro or in vivo ani...

    Authors: Godfrey Chi-Fung Chan, Wing Keung Chan and Daniel Man-Yuen Sze

    Citation: Journal of Hematology & Oncology 2009 2:25

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  6. Content type: Research

    The ability to screen blood of early stage operable breast cancer patients for circulating tumour cells is of potential importance for identifying patients at risk of developing distant relapse. We present the...

    Authors: Michael P Raynor, Sally-Anne Stephenson, Kenneth B Pittman, David CA Walsh, Michael A Henderson and Alexander Dobrovic

    Citation: Journal of Hematology & Oncology 2009 2:24

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  7. Content type: Review

    Acute myeloid leukemia (AML) is a heterogenous disorder that results from a block in the differentiation of hematopoietic progenitor cells along with uncontrolled proliferation. In approximately 60% of cases, ...

    Authors: Tara K Gregory, David Wald, Yichu Chen, Johanna M Vermaat, Yin Xiong and William Tse

    Citation: Journal of Hematology & Oncology 2009 2:23

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  8. Content type: Short report

    Cisplatin depletes MGMT and increases the sensitivity of leukemia cells to temozolomide. We performed a phase I study of cisplatin and temozolomide in patients with relapsed and refractory acute leukemia. Fift...

    Authors: Karen Seiter, Sreedhar Katragadda, Doris Ponce, Muhammad Rasul and Nasir Ahmed

    Citation: Journal of Hematology & Oncology 2009 2:21

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  9. Content type: Research

    Ezatiostat hydrochloride liposomes for injection, a glutathione S-transferase P1-1 inhibitor, was evaluated in myelodysplastic syndrome (MDS). The objectives were to determine the safety, pharmacokinetics, and...

    Authors: Azra Raza, Naomi Galili, Natalie Callander, Leonel Ochoa, Lawrence Piro, Peter Emanuel, Stephanie Williams, Howard Burris III, Stefan Faderl, Zeev Estrov, Peter Curtin, Richard A Larson, James G Keck, Marsha Jones, Lisa Meng and Gail L Brown

    Citation: Journal of Hematology & Oncology 2009 2:20

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  10. Content type: Case report

    Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder of unknown etiology and characterized by various clinical manifestations and multiple organ involvement. It has been reported in as...

    Authors: Zhen-gang Yuan, Xiao-yi Dun, Yong-hua Li and Jian Hou

    Citation: Journal of Hematology & Oncology 2009 2:19

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  11. Content type: Review

    Individualized therapies that are tailored to a patient's genetic composition will be of tremendous value for treatment of cancer. Recently, Kirsten ras (KRAS) status has emerged as a predictor of response to epi...

    Authors: David Z Chang, Vikas Kumar, Ying Ma, Kuiyuan Li and Scott Kopetz

    Citation: Journal of Hematology & Oncology 2009 2:18

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  12. Content type: Research

    We studied serum proteomic profiling in patients with graft versus host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) by two-dimensional gel electrophoresis (2-DE) and mass spec...

    Authors: Joseph McGuirk, Gang Hao, Weijian Hou, Sunil Abhyankar, Casey Williams, Weisi Yan, Jianda Yuan, Xiuqin Guan, Robert Belt, Shaun Dejarnette, Jeffery Wieman and Ying Yan

    Citation: Journal of Hematology & Oncology 2009 2:17

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  13. Content type: Research

    Malignant tumors that involve the skull base pose significant challenges to the clinician because of the proximity of critical neurovascular structures and limited effectiveness of surgical resection without m...

    Authors: Nicholas D Coppa, Daniel MS Raper, Ying Zhang, Brian T Collins, K William Harter, Gregory J Gagnon, Sean P Collins and Walter C Jean

    Citation: Journal of Hematology & Oncology 2009 2:16

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  14. Content type: Research

    Human β-globin disorders are relatively common genetic diseases cause by mutations in the β-globin gene. Increasing the expression of the γ-globin gene has great benefits in reducing complications associated with...

    Authors: Xiaoxin S Xu, Xin Hong and Gan Wang

    Citation: Journal of Hematology & Oncology 2009 2:15

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  15. Content type: Research

    R-CHOP (rituximab with cyclophosphamide, doxorubicin, vincristine and prednisone) and R-CVP (rituximab with cyclophosphamide, vincristine and prednisone) have both been used successfully in the treatment of pa...

    Authors: Ganguly Siddhartha and Patel Vijay

    Citation: Journal of Hematology & Oncology 2009 2:14

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  16. Content type: Research

    Metastatic pancreatic adenocarcinoma has a short median overall survival (OS) of 5–6 months. However, a subgroup of patients survives more than 1 year. We analyzed the survival outcomes of this subgroup and ev...

    Authors: Bernardo HL Goulart, Jeffrey W Clark, Gregory Y Lauwers, David P Ryan, Nina Grenon, Alona Muzikansky and Andrew X Zhu

    Citation: Journal of Hematology & Oncology 2009 2:13

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  17. Content type: Case report

    Cholestatic jaundice as a presenting symptom of Precursor T-lymphoblastic leukemia (T-ALL)/lymphoma (T-LBL) has never been reported in literature. Similarly, precursor T-ALL/T-LBL is characteristically negativ...

    Authors: Kevin J Patel, Sahibzada U Latif and Wanderley M de Calaca

    Citation: Journal of Hematology & Oncology 2009 2:12

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  18. Content type: Case report

    Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma (ALK-DLBCL) is a rare lymphoma with several clinicopathological differences from ALK-positive anaplastic large cell lymphoma (ALCL). The latest...

    Authors: Brady Beltran, Jorge Castillo, Renzo Salas, Pilar Quiñones, Domingo Morales, Fernando Hurtado, Luis Riva and Eric Winer

    Citation: Journal of Hematology & Oncology 2009 2:11

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  19. Content type: Review

    We have reviewed the pivotal presentations rcelated to colorectal cancer (CRC) and other gastrointestinal malignancies from 2008 annual meeting of the American Society of Clinical Oncology (ASCO). We have disc...

    Authors: Milind Javle and Chung-Tsen Hsueh

    Citation: Journal of Hematology & Oncology 2009 2:9

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  20. Content type: Research

    The Bcl-2 family of proteins is critical to the life and death of malignant B-lymphocytes. Interfering with their activity using small-molecule inhibitors (SMI) is being explored as a new therapeutic strategy ...

    Authors: Ayad M Al-Katib, Yuan Sun, Anton Scott Goustin, Asfar Sohail Azmi, Ben Chen, Amro Aboukameel and Ramzi M Mohammad

    Citation: Journal of Hematology & Oncology 2009 2:8

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  21. Content type: Research

    Recent research has supported that a variety of cytokines play important roles during radiation-induced lung toxicity. The present study is designed to investigate the differences in early cytokine induction a...

    Authors: Xiaoping Ao, Lujun Zhao, Mary A Davis, David M Lubman, Theodore S Lawrence and Feng-Ming Kong

    Citation: Journal of Hematology & Oncology 2009 2:6

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  22. Content type: Research

    We highlight the orbital manifestations of acute myeloid leukemia and the role of peripheral blood smear in the diagnosis of these cases. A total of 12 patients who presented with proptosis and were subsequent...

    Authors: Ramesh Murthy, Geeta K Vemuganti, Santosh G Honavar, Milind Naik and Vijayanand Reddy

    Citation: Journal of Hematology & Oncology 2009 2:4

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  23. Content type: Short report

    SET-NUP214 fusion resulting from a recurrent cryptic deletion, del(9)(q34.11q34.13) has recently been described in T-cell acute lymphoblastic leukemia (T-ALL) and in one case of acute myeloid leukemia (AML). The ...

    Authors: Hilmar Quentmeier, Björn Schneider, Sonja Röhrs, Julia Romani, Margarete Zaborski, Roderick AF MacLeod and Hans G Drexler

    Citation: Journal of Hematology & Oncology 2009 2:3

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  24. Content type: Research

    Curative surgery is not an option for many patients with clinical stage I non-small-cell lung carcinoma (NSCLC), but radical radiosurgery may be effective.

    Authors: Brian T Collins, Saloomeh Vahdat, Kelly Erickson, Sean P Collins, Simeng Suy, Xia Yu, Ying Zhang, Deepa Subramaniam, Cristina A Reichner, Ismet Sarikaya, Giuseppe Esposito, Shadi Yousefi, Carlos Jamis-Dow, Filip Banovac and Eric D Anderson

    Citation: Journal of Hematology & Oncology 2009 2:1

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  25. Content type: Case report

    Concurrent hemolysis in patients with vitamin B12 deficiency is a well-recognized phenomenon and has been attributed to intramedullary destruction of erythrocytes (ineffective erythropoiesis). Recent studies r...

    Authors: Utkarsh Acharya, Jen-Tzer Gau, William Horvath, Paolo Ventura, Chung-Tsen Hsueh and Wayne Carlsen

    Citation: Journal of Hematology & Oncology 2008 1:26

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  26. Content type: Research

    Prostate cancer remains the most common malignancy among elderly men and the second leading cause of cancer death in the United States. Although several conventional therapies are currently available, they hav...

    Authors: Paul Pyo, Brandon Louie, Srinivas Rajamahanty, Muhammad Choudhury and Sensuke Konno

    Citation: Journal of Hematology & Oncology 2008 1:25

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  27. Content type: Case report

    The etiology of venous thromboembolism in young patients is frequently associated with hereditary coagulation abnormalities, immunologic diseases, and neoplasia. The advent of radiological advances, namely Com...

    Authors: Cannon Milani, Maria Constantinou, David Berz, James N Butera and Gerald A Colvin

    Citation: Journal of Hematology & Oncology 2008 1:24

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  28. Content type: Research

    Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome (TTP-HUS) are related and uncommon disorders with a high fatality and complication rate if untreated. Plasma exchange therapy has been show...

    Authors: Mark Levandovsky, Danielle Harvey, Primo Lara and Ted Wun

    Citation: Journal of Hematology & Oncology 2008 1:23

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  29. Content type: Case report

    Antiandrogen withdrawal response is an increasingly recognized entity in patients with metastatic prostate cancer. To our knowledge, there have been no reports describing a durable radiologic improvement along wi...

    Authors: Yiu-Keung Lau, Manpreet K Chadha, Alan Litwin and Donald L Trump

    Citation: Journal of Hematology & Oncology 2008 1:21

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  30. Content type: Review

    This review summarizes phase I trial results of 11 drugs presented at the American Society of Clinical Oncology meeting held in Chicago IL from May 30 to June 3rd 2008: BMS-663513, CT-322, CVX-045, GDC-0449, G...

    Authors: Andrea Molckovsky and Lillian L Siu

    Citation: Journal of Hematology & Oncology 2008 1:20

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  31. Content type: Research

    Excessive maturation of hematopoietic cells leads to a reduction of long-term proliferative capability during cord blood (CB) expansion. In this study, we report the effects of anit-CD52 (Alemtuzumab, Campath)...

    Authors: Che K Lim, Li Sun, Qi Feng, Ping Law, Wei T Chua, Shy N Lim and William YK Hwang

    Citation: Journal of Hematology & Oncology 2008 1:19

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  32. Content type: Case report

    Hepatocellular carcinoma is rare, but increasing in prevalence in the United States. Recent studies have shown that sorafenib, a multikinase inhibitor, can reduce tumor progression in patients with this cancer...

    Authors: Brian J So, Tanios Bekaii-Saab, Mark A Bloomston and Tushar Patel

    Citation: Journal of Hematology & Oncology 2008 1:18

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  33. Content type: Research

    We have analyzed t(12;21)(p13:q22) in an attempt to evaluate the frequency and prognostic significance of TEL-AML1 fusion gene in patients with childhood CD 10 positive B-ALL by fluorescence in situ hybridization...

    Authors: Eman Mosad, Hosny B Hamed, Rania M Bakry, Azza M Ezz-Eldin and Nesrine M Khalifa

    Citation: Journal of Hematology & Oncology 2008 1:17

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  34. Content type: Review

    Breast cancer is the most common female cancer and the second most common cause of female cancer-related deaths in the United States. World-wide, more than one million women will be diagnosed with breast cance...

    Authors: David Chu and Janice Lu

    Citation: Journal of Hematology & Oncology 2008 1:16

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  35. Content type: Research

    L-arginine is the common substrate for the two isoforms of arginase. Arginase I, highly expressed in the liver and arginase II mainly expressed in the kidney. Arginase I-producing myeloid derived suppressor ce...

    Authors: David J Tate Jr, Derek J Vonderhaar, Yupanqui A Caldas, Toye Metoyer, John R Patterson IV, Diego H Aviles and Arnold H Zea

    Citation: Journal of Hematology & Oncology 2008 1:14

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  36. Content type: Research

    The most common semiquantitative method of evaluation of pulmonary lesions using 18F-FDG PET is FDG standardized uptake value (SUV). An SUV cutoff of 2.5 or greater has been used to differentiate between benign a...

    Authors: Majid Khalaf, Hani Abdel-Nabi, John Baker, Yiping Shao, Dominick Lamonica and Jayakumari Gona

    Citation: Journal of Hematology & Oncology 2008 1:13

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