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  1. Although the majority of published cases of lead poisoning come from occupational exposures, some traditional remedies may also contain toxic amounts of lead. Ayurveda is a system of traditional medicine that ...

    Authors: Krishna S Gunturu, Priyadharsini Nagarajan, Peter McPhedran, Thomas R Goodman, Michael E Hodsdon and Matthew P Strout

    Citation: Journal of Hematology & Oncology 2011 4:51

    Content type: Case report

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  2. Regulatory T cells (Tregs) are a specialized subpopulation of CD4+ T cells, which act to suppress the activation of other immune cells. Tregs represent important modulators for the interaction between lymphomas a...

    Authors: Jing Wang and Xiao-Yan Ke

    Citation: Journal of Hematology & Oncology 2011 4:50

    Content type: Review

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  3. Most non-Hodgkin's lymphomas (NHL) initially respond to chemotherapy, but relapse is common and treatment is often limited by chemotherapy-related toxicity. Bortezomib, is a highly selective proteasome inhibit...

    Authors: Shiloh M Martin, Eric Churchill, Hayes McKnight, Christopher M Mahaffey, Yunpeng Ma, Robert T O'Donnell and Joseph M Tuscano

    Citation: Journal of Hematology & Oncology 2011 4:49

    Content type: Research

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  4. Regulatory T cells (Treg) that express the transcription factor Foxp3 are enriched within a broad range of murine and human solid tumors. The ontogeny of these Foxp3 Tregs - selective accumulation or prolifera...

    Authors: Jon G Quatromoni, Lilah F Morris, Timothy R Donahue, Yue Wang, William McBride, Talal Chatila and James S Economou

    Citation: Journal of Hematology & Oncology 2011 4:48

    Content type: Research

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  5. Light chain (AL) amyloidosis is a plasma cell dyscrasia characterized by the pathologic production of fibrillar proteins comprised of monoclonal light chains which deposit in tissues and cause organ dysfunctio...

    Authors: Michael Rosenzweig and Heather Landau

    Citation: Journal of Hematology & Oncology 2011 4:47

    Content type: Review

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  6. The regimen of cytarabine, aclarubicin and G-CSF (CAG) has been widely used in China and Japan for treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We searched literature on CAG be...

    Authors: Guoqing Wei, Wanmao Ni, Jen-wei Chiao, Zhen Cai, He Huang and Delong Liu

    Citation: Journal of Hematology & Oncology 2011 4:46

    Content type: Research

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  7. Acute megakaryoblastic leukemia (AMKL) is a type of acute myeloid leukemia (AML), in which majority of the blasts are megakaryoblastic. De novo AMKL in adulthood is rare, and carries very poor prognosis. We he...

    Authors: Xiao Min, Zhang Na, Liu Yanan and Li Chunrui

    Citation: Journal of Hematology & Oncology 2011 4:45

    Content type: Case report

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  8. Anti-platelet therapy plays an important role in the treatment of patients with thrombotic diseases. The most commonly used anti-platelet drugs, namely, aspirin, ticlopidine, and clopidogrel, are effective in ...

    Authors: Xuebin Ji and Ming Hou

    Citation: Journal of Hematology & Oncology 2011 4:44

    Content type: Review

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  9. Idiopathic chronic neutropenia (ICN) describes a heterogeneous group of hematologic diseases characterized by low circulating neutrophil levels often associated with recurrent fevers, chronic mucosal inflammat...

    Authors: Roger M Lyons, Sharon T Wilks, Shelby Young and Gail L Brown

    Citation: Journal of Hematology & Oncology 2011 4:43

    Content type: Case report

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  10. The MRC UKALLXI trial tested the efficacy of different central nervous system (CNS) directed therapies in childhood acute lymphoblastic leukaemia (ALL). To evaluate morbidity 555/1826 randomised children under...

    Authors: Christina Halsey, Georgina Buck, Sue Richards, Faraneh Vargha-Khadem, Frank Hill and Brenda Gibson

    Citation: Journal of Hematology & Oncology 2011 4:42

    Content type: Research

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  11. Ph- myeloproliferative neoplasms (MPNs) represent a heterogeneous group of chronic diseases characterized by increased expansion of hematopoietic cells of the myeloid lineage. JAK2V617F, an activation mutation...

    Authors: Anna H Zhao, Rufei Gao and Zhizhuang J Zhao

    Citation: Journal of Hematology & Oncology 2011 4:40

    Content type: Short report

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  12. A 54-year-old woman was diagnosed with infiltrative ductal breast carcinoma. Two years after treatment, the patient developed an acute myeloid leukemia (AML) which harbored del(11q23) in 8% of the blast cells....

    Authors: Hilda Rachel Diamond, Maria Helena Ornellas, Alberto Orfao, Bernadete E Gomes, Mércia M Campos, Teresa S Fernandez, Roberto I da Silva, Gilda Alves, Claudia Lage, Dayse A da Silva, Arthur Moellmann-Coelho, Geydson S da Cruz, Luis Fernando Bouzas and Eliana Abdelhay

    Citation: Journal of Hematology & Oncology 2011 4:39

    Content type: Case report

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  13. Sall4 is a key factor for the maintenance of pluripotency and self-renewal of embryonic stem cells (ESCs). Our previous studies have shown that Sall4 is a robust stimulator for human hematopoietic stem and pro...

    Authors: Jianchang Yang, Jerell R Aguila, Zaida Alipio, Raymond Lai, Louis M Fink and Yupo Ma

    Citation: Journal of Hematology & Oncology 2011 4:38

    Content type: Research

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  14. The bone marrow microenvironment facilitates the survival, differentiation, and proliferation of myeloma (MM) cells. This study identified that microRNA-15a and -16 expressions tightly correlated with prolifer...

    Authors: Mu Hao, Li Zhang, Gang An, Weiwei Sui, Zhen Yu, Dehui Zou, Yan Xu, Hong Chang and Lugui Qiu

    Citation: Journal of Hematology & Oncology 2011 4:37

    Content type: Letter to the Editor

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  15. Bladder cancer occurs in the majority of cases in males. It represents the seventh most common cancer and the ninth most common cause of cancer deaths for men. Transitional cell carcinoma is the most predomina...

    Authors: Nabil Ismaili, Mounia Amzerin and Aude Flechon

    Citation: Journal of Hematology & Oncology 2011 4:35

    Content type: Review

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  16. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of aggressive T-cell lymphomas with poor treatment outcomes. The aim of this study was to evaluate whether lymphopenia at...

    Authors: Yu Ri Kim, Jin Seok Kim, Soo Jeong Kim, Hyun Ae Jung, Seok Jin Kim, Won Seog Kim, Hye Won Lee, Hyeon Seok Eom, Seong Hyun Jeong, Joon Seong Park, June-Won Cheong and Yoo Hong Min

    Citation: Journal of Hematology & Oncology 2011 4:34

    Content type: Research

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  17. The role of thymidylate synthase (TS) is essential as a key rate-limiting enzyme in DNA synthesis. It is the primary target of fluorouracil and its derivates in colorectal cancer. In this study, TS mRNA expres...

    Authors: Yanyan Liu, Qingxin Xia, Yanzhao Jia, Hongqiang Guo, Bing Wei, Yawei Hua and Shujun Yang

    Citation: Journal of Hematology & Oncology 2011 4:33

    Content type: Letter to the Editor

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  18. Nilotinib is approved for treatment of newly diagnosed chronic myeloid leukemia (CML) and it is shown superiority over imatinib in first-line treatment for patients of CML. In this study, we established a nilo...

    Authors: Seiichi Okabe, Tetsuzo Tauchi, Yuko Tanaka and Kazuma Ohyashiki

    Citation: Journal of Hematology & Oncology 2011 4:32

    Content type: Letter to the Editor

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  19. Pancreatic neuroendocrine tumors (NET) have diverse clinical presentations. Patients with symptoms of hormone secretion may require specific medical interventions to control those symptoms prior to antitumor i...

    Authors: Matthew H Kulke, Johanna Bendell, Larry Kvols, Joel Picus, Rodney Pommier and James Yao

    Citation: Journal of Hematology & Oncology 2011 4:29

    Content type: Review

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  20. Granulocyte colony stimulating factor (G-CSF) regulates survival, proliferation, and differentiation of neutrophilic granulocyte precursors, Recombinant G-CSF has been used for the treatment of congenital and ...

    Authors: Yongping Jiang, Wenhong Jiang, Yuchang Qiu and Wei Dai

    Citation: Journal of Hematology & Oncology 2011 4:28

    Content type: Research

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  21. Hemangiopericytoma is a rare and aggressive meningeal tumor. Although surgical resection is the standard treatment, hemangiopericytomas often recur with high incidences of metastasis. The purpose of this study...

    Authors: Anand Veeravagu, Bowen Jiang, Chirag G Patil, Marco Lee, Scott G Soltys, Iris C Gibbs and Steven D Chang

    Citation: Journal of Hematology & Oncology 2011 4:26

    Content type: Research

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  22. Although evaluation of at least 12 lymph nodes (LNs) is recommended as the minimum number of nodes required for accurate staging of colon cancer patients, there is disagreement on what constitutes an adequate ...

    Authors: Chandrakumar Shanmugam, Robert B Hines, Nirag C Jhala, Venkat R Katkoori, Bin Zhang, James A Posey Jr, Harvey L Bumpers, William E Grizzle, Isam E Eltoum, Gene P Siegal and Upender Manne

    Citation: Journal of Hematology & Oncology 2011 4:25

    Content type: Research

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  23. Endothelial progenitor cells are increasingly being studied in various diseases ranging from ischemia, diabetic retinopathy, and in cancer. The discovery that these cells can be mobilized from their bone marro...

    Authors: Andrea L George, Pradeep Bangalore-Prakash, Shilpi Rajoria, Robert Suriano, Arulkumaran Shanmugam, Abraham Mittelman and Raj K Tiwari

    Citation: Journal of Hematology & Oncology 2011 4:24

    Content type: Review

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  24. Downregulation of the B-cell chronic lymphocytic leukemia (CLL)/lymphoma11B (BCL11B) gene by small interfering RNA (siRNA) leads to growth inhibition and apoptosis of the human T-cell acute lymphoblastic leukemia...

    Authors: Xin Huang, Qi Shen, Si Chen, Shaohua Chen, Lijian Yang, Jianyu Weng, Xin Du, Piotr Grabarczyk, Grzegorz K Przybylski, Christian A Schmidt and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2011 4:23

    Content type: Short report

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  25. The matrix protein osteopontin has been shown to be a marker of osteoclastic activity in multiple myeloma patients, as well as a regulator of angiogenesis. We measured serum levels of osteopontin in 50 untreat...

    Authors: Aikaterini Sfiridaki, Spiros Miyakis, Constantina Pappa, George Tsirakis, Athanasios Alegakis, Vasileios Kotsis, Efstathios Stathopoulos and Michael Alexandrakis

    Citation: Journal of Hematology & Oncology 2011 4:22

    Content type: Letter to the Editor

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  26. Recently, we clarified at the molecular level novel chromosomal translocation t(14;14)(q11;q32) in a case of Sézary syndrome, which caused a rearrangement from TRAJ7 to the PPP2R5C gene. PPP2R5C is one of the reg...

    Authors: Haitao Zheng, Yu Chen, Shaohua Chen, Yuzhe Niu, Lijian Yang, Bo Li, Yuhong Lu, Suxia Geng, Xin Du and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2011 4:21

    Content type: Short report

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  27. Differentiation of the acute myeloid leukemia (AML) cell line HL-60 can be induced by all trans-retinoic acid (ATRA); however, the mechanism regulating this process has not been fully characterized.

    Authors: Pan Jian, Zhao Wen Li, Tao Yan Fang, Wang Jian, Zhou Zhuan, Liao Xin Mei, Wu Shui Yan and Ni Jian

    Citation: Journal of Hematology & Oncology 2011 4:20

    Content type: Research

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  28. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) leads to a prolonged state of immunodeficiency and requires reconstitution of normal T-cell immunity. Signal joint T-cell receptor excision DNA ci...

    Authors: Xiuli Wu, Kanger Zhu, Xin Du, Shaohua Chen, Lijian Yang, Jufeng Wu, Qifa Liu and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2011 4:19

    Content type: Research

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  29. We reviewed preclinical data and clinical development of MDM2 (murine double minute 2), ALK (anaplastic lymphoma kinase) and PARP (poly [ADP-ribose] polymerase) inhibitors. MDM2 binds to p53, and promotes degr...

    Authors: Yuan Yuan, Yu-Min Liao, Chung-Tsen Hsueh and Hamid R Mirshahidi

    Citation: Journal of Hematology & Oncology 2011 4:16

    Content type: Review

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  30. Endometrial carcinoma is one of the most common gynecological malignancies in women. The diagnosis of the disease at early or premalignant stages is crucial for the patient's prognosis. To date, diagnosis and ...

    Authors: Yi-sheng Wang, Rui Cao, Hong Jin, Yi-ping Huang, Xiao-yan Zhang, Qing Cong, Yi-feng He and Cong-jian Xu

    Citation: Journal of Hematology & Oncology 2011 4:15

    Content type: Short report

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  31. The CyberKnife is an appealing delivery system for hypofractionated stereotactic body radiation therapy (SBRT) because of its ability to deliver highly conformal radiation therapy to moving targets. This confo...

    Authors: Eric K Oermann, Simeng Suy, Heather N Hanscom, Joy S Kim, Sue Lei, Xia Yu, Guowei Zhang, Brook Ennis, JoyAnn P Rohan, Nathaniel Piel, Benjamin A Sherer, Devin Borum, Viola J Chen, Gerald P Batipps, Nicholas L Constantinople, Stephen W Dejter…

    Citation: Journal of Hematology & Oncology 2011 4:12

    Content type: Research

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  32. The objectives of the present study are to investigate the efficacy and safety profile of gemcitabine-based combinations in the treatment of locally advanced and metastatic pancreatic adenocarcinoma (LA/MPC).

    Authors: Jing Hu, Gang Zhao, Hong-Xia Wang, Lei Tang, Ying-Chun Xu, Yue Ma and Feng-Chun Zhang

    Citation: Journal of Hematology & Oncology 2011 4:11

    Content type: Research

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  33. Mast cell activation disease comprises disorders characterized by accumulation of genetically altered mast cells and/or abnormal release of these cells' mediators, affecting functions in potentially every orga...

    Authors: Gerhard J Molderings, Stefan Brettner, Jürgen Homann and Lawrence B Afrin

    Citation: Journal of Hematology & Oncology 2011 4:10

    Content type: Review

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  34. Acute leukemia with coexisting Gilbert's syndrome treated by allogeneic hematopoietic stem cell transplantation (allo-HSCT) is rarely reported. Here we described a case whose transaminase levels were almost no...

    Authors: Guo-Pan Yu, Qian-Li Jiang, Zhi-Ping Fan, Jie Zhao, Qi Wei, Jing Sun, Fan-Yi Meng and Qi-Fa Liu

    Citation: Journal of Hematology & Oncology 2011 4:9

    Content type: Letter to the Editor

    Published on:

  35. The unfolded protein response ( UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer c...

    Authors: Xuemei Li, Kezhong Zhang and Zihai Li

    Citation: Journal of Hematology & Oncology 2011 4:8

    Content type: Review

    Published on:

  36. BCR-ABL kinase domain (KD) mutation is the major mechanism contributing to suboptimal response to tyrosine kinase inhibitors (TKI) in BCR-ABL-positive chronic myeloid leukemia (CML) patients. T315I mutation, as o...

    Authors: Wanwisa Wongboonma, Wanna Thongnoppakhun and Chirayu U Auewarakul

    Citation: Journal of Hematology & Oncology 2011 4:7

    Content type: Research

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  37. The BCR-ABL1 translocation occurs in chronic myeloid leukemia (CML) and in 25% of cases with acute lymphoblastic leukemia (ALL). The advent of tyrosine kinase inhibitors (TKI) has fundamentally changed the treatm...

    Authors: Hilmar Quentmeier, Sonja Eberth, Julia Romani, Margarete Zaborski and Hans G Drexler

    Citation: Journal of Hematology & Oncology 2011 4:6

    Content type: Research

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  38. Chemotherapy combined concurrently with TKIs produced a negative interaction and failed to improve survival when compared with chemotherapy or TKIs alone in the treatment of non-small cell lung cancer (NSCLC)....

    Authors: Hua Cheng, She-Juan An, Song Dong, Yi-Fang Zhang, Xu-Chao Zhang, Zhi-Hong Chen, Jian-Su and Yi-Long Wu

    Citation: Journal of Hematology & Oncology 2011 4:5

    Content type: Research

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  39. JAK2V617F is found in the majority of patients with Ph- myeloproliferative neoplasms (MPNs) and has become a valuable marker for diagnosis of MPNs. However, it has also been found in many other hematological d...

    Authors: Wanming Zhao, Rufei Gao, Jiyun Lee, Shu Xing, Wanting T Ho, Xueqi Fu, Shibo Li and Zhizhuang J Zhao

    Citation: Journal of Hematology & Oncology 2011 4:4

    Content type: Short report

    Published on:

  40. This phase I, randomized, multicenter, open-label study investigated the pharmacokinetics, safety, and efficacy of the oral mammalian target of rapamycin inhibitor everolimus in Chinese patients with advanced ...

    Authors: BingHe Xu, YiLong Wu, Lin Shen, DingWei Ye, Annette Jappe, Azzeddine Cherfi, Hui Wang and RuiRong Yuan

    Citation: Journal of Hematology & Oncology 2011 4:3

    Content type: Research

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  41. Our previous study had amplified antigen-specific full-length TCR α and β genes of clonally expanded T cells in the peripheral blood (PB) of patients with diffuse large B-cell lymphoma (DLBCL). The transfer of...

    Authors: Qingsong Yin, Xianfeng Zha, Lijian Yang, Shaohua Chen, Yubing Zhou, Xiuli Wu and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2011 4:2

    Content type: Research

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