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  1. Systemic anaplastic large cell lymphoma (S-ALCL) is a rare disease with a highly variable prognosis and no standard chemotherapy regimen. Anaplastic lymphoma kinase (ALK) has been reported as an important prog...

    Authors: Yan-Fang Wang, Yan-Li Yang, Zi-Fen Gao, Chun-Ju Zhou, Xylina Gregg, Yun-Fei Shi, Jing Wang, Xiao-Feng Yang and Xiao-Yan Ke

    Citation: Journal of Hematology & Oncology 2012 5:38

    Content type: Research

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  2. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors occurring mainly in patients with chronic liver disease. Detection of early HCC is critically important for treatment of these patients.

    Authors: Yantong Guo, Jingming Zhao, Jingtao Bi, Quan Wu, Xin Wang and Quanyou Lai

    Citation: Journal of Hematology & Oncology 2012 5:37

    Content type: Short report

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  3. Men with metastatic castration-resistant prostate cancer (mCRPC) carry poor prognosis despite the use of docetaxel-based regimens which has modest survival benefit shown by randomized clinical trials. Signific...

    Authors: Xuan Huang, Cindy H Chau and William D Figg

    Citation: Journal of Hematology & Oncology 2012 5:35

    Content type: Review

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  4. Multiple immunotherapy approaches have improved adaptive anti-tumor immune responses in patients with early stage disease; however, results have been less dramatic when treating patients with late stage diseas...

    Authors: Jarrod D Predina, Veena Kapoor, Brendan F Judy, Guanjun Cheng, Zvi Gregory Fridlender, Steven M Albelda and Sunil Singhal

    Citation: Journal of Hematology & Oncology 2012 5:34

    Content type: Research

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  5. Autologous stem cell transplantation (ASCT) is the gold standard therapy for suitable multiple myeloma (MM) patients after induction with high dose therapy. To date, the evidence of a reliable marker of progno...

    Authors: Cristina Guimarães, Rui Bergantim, Renata Ramalho, Nuno Couto, João T Guimarães and Fernanda Trigo

    Citation: Journal of Hematology & Oncology 2012 5:33

    Content type: Letter to the Editor

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  6. Ribosomes are essential components of the protein translation machinery and are composed of more than 80 unique large and small ribosomal proteins. Recent studies show that in addition to their roles in protei...

    Authors: Niraj Shenoy, Rachel Kessel, Tushar D Bhagat, Sanchari Bhattacharyya, Yiting Yu, Christine Mcmahon and Amit Verma

    Citation: Journal of Hematology & Oncology 2012 5:32

    Content type: Review

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  7. Contemporary advancements have had little impact on the treatment of gastric cancer (GC), the world’s second highest cause of cancer death. Agents targeting human epidermal growth factor receptor mediated path...

    Authors: Lian Liu, Ning Wu and Jin Li

    Citation: Journal of Hematology & Oncology 2012 5:31

    Content type: Review

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  8. Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disorder of elderly people. Cardiac dysfunction is a marker of grim prognosis in MDS. We evaluated cardiac dysfunction of MDS patients with or...

    Authors: Cláudio César Monteiro de Castro, Carlos Bellini Gondim Gomes, Manoel Ricardo Alves Martins, Juliana Cordeiro de Sousa, Silvia MM Magalhaes and Ronald F Pinheiro

    Citation: Journal of Hematology & Oncology 2012 5:30

    Content type: Letter to the Editor

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  9. Maintenance therapy with imatinib during the post-transplant period has been used for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL); however, its efficacy has not been ...

    Authors: Huan Chen, Kai-yan Liu, Lan-ping Xu, Dai-hong Liu, Yu-hong Chen, Xiang-yu Zhao, Wei Han, Xiao-hui Zhang, Yu Wang, Yuan-yuan Zhang, Ya-zhen Qin, Yan-rong Liu and Xiao-jun Huang

    Citation: Journal of Hematology & Oncology 2012 5:29

    Content type: Research

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  10. We have reported promising outcomes using a staged approach, in which bortezomib/thalidomide/dexamethasone was used only in 14 patients with suboptimal response to VAD (vincristine/adriamycin/dexamethasone) be...

    Authors: Chor Sang Chim, Albert Kwok Wai Lie, Eric Yuk Tat Chan, Herman Sung Yu Liu, Ching Wa Lau, Sze Fai Yip, Joycelyn Sim, Thomas Shek-Kong Wan, Edmond Shiu-Kwan Ma, Raymond Liang, Eric Tse and Yok-Lam Kwong

    Citation: Journal of Hematology & Oncology 2012 5:28

    Content type: Research

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  11. Extranodal nasal-type NK/T-cell lymphoma is a rare and severe disease. Considering the rarity of this lymphoma in Europe, we conducted a multicentric retrospective study on nasal-type NK/T cell lymphoma to det...

    Authors: Adrien Chauchet, Anne-Sophie Michallet, Françoise Berger, Isabelle Bedgedjian, Eric Deconinck, Catherine Sebban, Daciana Antal, Hubert Orfeuvre, Bernadette Corront, Tony Petrella, Maya Hacini, Marie Bouteloup, Gilles Salles and Bertrand Coiffier

    Citation: Journal of Hematology & Oncology 2012 5:27

    Content type: Research

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  12. MicroRNA have a central role in normal haematopoiesis and are deregulated in acute myeloid leukaemia (AML). The purpose of the study was to investigate by qRT-PCR the expression of miRNAs involved in myeloid d...

    Authors: Isabella Faraoni, Serena Laterza, Davide Ardiri, Claudia Ciardi, Francesco Fazi and Francesco Lo-Coco

    Citation: Journal of Hematology & Oncology 2012 5:26

    Content type: Rapid communication

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  13. Chronic lymphocytic leukemia (CLL) is the rarest adult leukemia in Japan, whereas it is the most common leukemia in the Western world. Recent studies from the United States and Germany suggest a possible etiol...

    Authors: Masayuki Imajoh, Yumiko Hashida, Ayuko Taniguchi, Mikio Kamioka and Masanori Daibata

    Citation: Journal of Hematology & Oncology 2012 5:25

    Content type: Rapid communication

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  14. Mycosis fungoides (MF) and Sezary Syndrome (SS) represent the most common subtypes of primary Cutaneous T-cell lymphoma (CTCL). Patients with advanced MF and SS have a poor prognosis leading to an interest in ...

    Authors: Salvia Jain, Jasmine Zain and Owen O’Connor

    Citation: Journal of Hematology & Oncology 2012 5:24

    Content type: Review

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  15. The BCR-ABL T315I kinase domain mutation is insensitive to dasatinib therapy for Philadelphia-positive acute lymphoid leukemia (Ph + ALL) patients. Resistant T315I clone may be present prior to initiating dasa...

    Authors: Naoto Takahashi, Masatomo Miura, Stuart A Scott, Takenori Niioka and Kenichi Sawada

    Citation: Journal of Hematology & Oncology 2012 5:23

    Content type: Short report

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  16. Although the importance of the hematopoietic transcription factor PU.1 in acute myeloid leukemia (AML) has been demonstrated, the expression of PU.1 in acute promyelocytic leukemia (APL) patient samples awaits...

    Authors: Xuehua Zhu, Hui Zhang, Maoxiang Qian, Xujie Zhao, Wentao Yang, Ping Wang, Ji Zhang and Kankan Wang

    Citation: Journal of Hematology & Oncology 2012 5:22

    Content type: Rapid communication

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  17. The discovery of CD117 mutation in almost all gastrointestinal stromal tumors (GISTs) marked a milestone. Other spindle cell neoplasms arising from the GI tract including lipoma, schwannoma, hemangioma, leiomy...

    Authors: Gurpreet Lamba, Samir Ambrale, Byung Lee, Ridhi Gupta, Shamudheen M Rafiyath and Delong Liu

    Citation: Journal of Hematology & Oncology 2012 5:21

    Content type: Review

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  18. Approximately 70% of all patients with myelodysplastic syndrome (MDS) present with lower-risk disease. Some of these patients will initially respond to treatment with growth factors to improve anemia but will ...

    Authors: Naomi Galili, Pablo Tamayo, Olga B Botvinnik, Jill P Mesirov, Margarita R Brooks, Gail Brown and Azra Raza

    Citation: Journal of Hematology & Oncology 2012 5:20

    Content type: Research

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  19. Mesenchymal stem cells (MSC) have generated a great amount of enthusiasm over the past decade as a novel therapeutic paradigm for a variety of diseases. Currently, MSC based clinical trials have been conducted...

    Authors: Shihua Wang, Xuebin Qu and Robert Chunhua Zhao

    Citation: Journal of Hematology & Oncology 2012 5:19

    Content type: Review

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  20. Ezatiostat, a glutathione S-transferase P1-1 inhibitor, promotes the maturation of hematopoietic progenitors and induces apoptosis in cancer cells.

    Authors: Azra Raza, Naomi Galili, Deborah Mulford, Scott E Smith, Gail L Brown, David P Steensma, Roger M Lyons, Ralph Boccia, Mikkael A Sekeres, Guillermo Garcia-Manero and Ruben A Mesa

    Citation: Journal of Hematology & Oncology 2012 5:18

    Content type: Research

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  21. Recombinant human arginase (rhArg) has been developed for arginine deprivation therapy in cancer, and is currently under clinical investigation. During pre-clinical evaluation, rhArg has exhibited significant ...

    Authors: Eddy C Hsueh, Stephanie M Knebel, Wai-Hung Lo, Yun-Chung Leung, Paul Ning-Man Cheng and Chung-Tsen Hsueh

    Citation: Journal of Hematology & Oncology 2012 5:17

    Content type: Research

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  22. Tissue factor (TF), an initiator of blood coagulation, participates in cancer progression and metastasis. We recently found that inhibition of MAPK/ERK upregulated both full length TF (flTF) and soluble isofor...

    Authors: Chaoquan Hu, Limin Huang, Caroline Gest, Xiaodong Xi, Anne Janin, Claudine Soria, Hong Li and He Lu

    Citation: Journal of Hematology & Oncology 2012 5:16

    Content type: Research

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  23. Cell division cycle 20 (CDC20) homolog is an anaphase-promoting complex activator that is essential for cell division, but whether its expression in pancreatic ductal adenocarcinoma (PDAC) is significant is un...

    Authors: David Z Chang, Ying Ma, Baoan Ji, Yan Liu, Patrick Hwu, James L Abbruzzese, Craig Logsdon and Huamin Wang

    Citation: Journal of Hematology & Oncology 2012 5:15

    Content type: Research

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  24. Peripheral blood stem cell (PBSC) mobilization, which uses plerixafor (AMD 3100), a newly developed specific inhibitor of the CXCR4 receptor, in combination with granulocyte-colony stimulating factor(G-CSF), h...

    Authors: Kyung Taek Hong, Hyoung Jin Kang, Nam Hee Kim, Min Sun Kim, Ji Won Lee, Hyery Kim, Kyung Duk Park, Hee Young Shin and Hyo Seop Ahn

    Citation: Journal of Hematology & Oncology 2012 5:14

    Content type: Letter to the Editor

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  25. The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations a...

    Authors: Véronique Gelsi-Boyer, Mandy Brecqueville, Raynier Devillier, Anne Murati, Marie-Joelle Mozziconacci and Daniel Birnbaum

    Citation: Journal of Hematology & Oncology 2012 5:12

    Content type: Review

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  26. MicroRNAs (miRNAs) are short non-coding RNAs that are involved in several important biological processes through regulation of genes post-transcriptionally. Carcinogenesis is one of the key biological processe...

    Authors: Oudai Hassan, Aamir Ahmad, Seema Sethi and Fazlul H Sarkar

    Citation: Journal of Hematology & Oncology 2012 5:9

    Content type: Review

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  27. MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show ...

    Authors: Thilini R Fernando, Norma I Rodriguez-Malave and Dinesh S Rao

    Citation: Journal of Hematology & Oncology 2012 5:7

    Content type: Review

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  28. Aplastic anemia (AA) is characterized by pancytopenia and bone marrow hypoplasia, which results from immune-mediated hematopoiesis suppression. Understanding the pathophysiology of the immune system, particula...

    Authors: Bo Li, Sichu Liu, Yuzhe Niu, Su Fang, Xiuli Wu, Zhi Yu, Shaohua Chen, Lijian Yang and Yangqiu Li

    Citation: Journal of Hematology & Oncology 2012 5:6

    Content type: Rapid communication

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  29. Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes encode cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to α-ketoglutarate. Acquired somatic mutations of IDH1 and ID...

    Authors: Sadudee Chotirat, Wanna Thongnoppakhun, Orathai Promsuwicha, Chetsada Boonthimat and Chirayu U Auewarakul

    Citation: Journal of Hematology & Oncology 2012 5:5

    Content type: Research

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  30. While lenalidomide (LEN) shows high efficacy in myelodysplastic syndromes (MDS) with del[5q], responses can be also seen in patients presenting without del[5q]. We hypothesized that improved detection of chrom...

    Authors: Yuka Sugimoto, Mikkael A Sekeres, Hideki Makishima, Fabiola Traina, Valeria Visconte, Anna Jankowska, Andres Jerez, Hadrian Szpurka, Christine L O'Keefe, Kathryn Guinta, Manuel Afable, Ramon Tiu, Kathy L McGraw, Alan F List and Jaroslaw Maciejewski

    Citation: Journal of Hematology & Oncology 2012 5:4

    Content type: Research

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  31. Advanced malignant melanoma remains a challenging cancer. Over the past year, there have been 3 agents approved for treatment of melanoma by Food and Drug Administration. These include pegylated interferon alp...

    Authors: Byung Lee, Nikhil Mukhi and Delong Liu

    Citation: Journal of Hematology & Oncology 2012 5:3

    Content type: Review

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  32. Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) are Chronic Myeloproliferative Neoplasms (MPN) characterized by clonal myeloproliferation/myeloaccumulation without cell maturation impairment. Th...

    Authors: Raquel Tognon, Elainy PL Gasparotto, Renata P Neves, Natália S Nunes, Aline F Ferreira, Patrícia VB Palma, Simone Kashima, Dimas T Covas, Mary Santana, Elizabeth X Souto, Maria Aparecida Zanichelli, Belinda P Simões, Ana Maria de Souza and Fabíola A Castro

    Citation: Journal of Hematology & Oncology 2012 5:2

    Content type: Research

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  33. Speciation of arsenic trioxide (ATO) metabolites in clinical samples such as peripheral blood (PB) from acute promyelocytic leukemia (APL) patients has been conducted. However, speciation of arsenicals in bone...

    Authors: Noriyoshi Iriyama, Yuta Yoshino, Bo Yuan, Akira Horikoshi, Yukio Hirabayashi, Yoshihiro Hatta, Hiroo Toyoda and Jin Takeuchi

    Citation: Journal of Hematology & Oncology 2012 5:1

    Content type: Research

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  34. Infantile hemangiomas (IH) are the most common benign tumors of infancy. The typical clinical course consists of rapid growth during the first year of life, followed by natural and gradual involution over a mu...

    Authors: Dan Xu, Teresa M O, Archil Shartava, Taylor C Fowles, Jianchang Yang, Louis M Fink, David C Ward, Martin C Mihm, Milton Waner and Yupo Ma

    Citation: Journal of Hematology & Oncology 2011 4:54

    Content type: Research

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  35. Dabigatran is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity. It has been approved in the European Union and the United States of America for the prevention of thrombosis after...

    Authors: Santiago Redondo, Maria-Paz Martínez, Marta Ramajo, Jorge Navarro-Dorado, Abelardo Barez and Teresa Tejerina

    Citation: Journal of Hematology & Oncology 2011 4:53

    Content type: Review

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  36. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various tumor cells, but does not affect normal cells or human leukemic cells, such as MOLT-4 and U937 cells, which are rela...

    Authors: Benjawan Wudtiwai, Bungorn Sripanidkulchai, Prachya Kongtawelert and Ratana Banjerdpongchai

    Citation: Journal of Hematology & Oncology 2011 4:52

    Content type: Research

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  37. Although the majority of published cases of lead poisoning come from occupational exposures, some traditional remedies may also contain toxic amounts of lead. Ayurveda is a system of traditional medicine that ...

    Authors: Krishna S Gunturu, Priyadharsini Nagarajan, Peter McPhedran, Thomas R Goodman, Michael E Hodsdon and Matthew P Strout

    Citation: Journal of Hematology & Oncology 2011 4:51

    Content type: Case report

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