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  1. Programmed cell death 1 (PD-1) and its ligand 1 (PD-L1) inhibitors have quickly become standard of care for patients with advanced non-small cell lung cancer and increasing numbers of other cancer types. In th...

    Authors: Hong Li, Weijie Ma, Ken Y. Yoneda, Elizabeth H. Moore, Yanhong Zhang, Lee L. Q. Pu, Garrett M. Frampton, Michael Molmen, Philip J. Stephens and Tianhong Li
    Citation: Journal of Hematology & Oncology 2017 10:64
  2. An increased expression of Yes-associated protein (YAP1) has been shown to promote tumorigenesis in many cancer types including colon. However, the role of YAP1 in promoting colon tumorigenesis remains unclear...

    Authors: Yan-Jiun Huang, Ching-Kuo Yang, Po-Li Wei, Thanh-Tuan Huynh, Jacqueline Whang-Peng, Tzu-Ching Meng, Michael Hsiao, Yew-Ming Tzeng, Alexander TH Wu and Yun Yen
    Citation: Journal of Hematology & Oncology 2017 10:60
  3. Arsenic trioxide (ATO) is commonly used in the treatment of acute promyelocytic leukemia (APL), but does not benefit patients with solid tumors. When combined with other agents or radiation, ATO showed treatme...

    Authors: Sunbin Ling, Haiyang Xie, Fan Yang, Qiaonan Shan, Haojiang Dai, Jianyong Zhuo, Xuyong Wei, Penghong Song, Lin Zhou, Xiao Xu and Shusen Zheng
    Citation: Journal of Hematology & Oncology 2017 10:59
  4. Extracellular vesicles (EVs) are small membranous vesicles secreted from numerous cell types and have been found involved in cell-to-cell communication by transferring noncoding RNAs (ncRNAs) including microRN...

    Authors: Pei Ma, Yutian Pan, Wei Li, Chongqi Sun, Jie Liu, Tongpeng Xu and Yongqian Shu
    Citation: Journal of Hematology & Oncology 2017 10:57
  5. Although blinatumomab, a bispecific T cell engaging antibody, exhibits high clinical response rates in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (B-ALL) and B cell non-Hodgk...

    Authors: Xiaolong Zhang, Yuanyuan Yang, Leisheng Zhang, Yang Lu, Qing Zhang, Dongmei Fan, Yizhi Zhang, Yanjun Zhang, Zhou Ye and Dongsheng Xiong
    Citation: Journal of Hematology & Oncology 2017 10:56
  6. The randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial evaluated the JAK1/JAK2 inhibitor ruxolitinib in patients with intermediate-2/high-risk myelofibrosis. The primary and planned 3-year a...

    Authors: Srdan Verstovsek, Ruben A. Mesa, Jason Gotlib, Vikas Gupta, John F. DiPersio, John V. Catalano, Michael W. N. Deininger, Carole B. Miller, Richard T. Silver, Moshe Talpaz, Elliott F. Winton, Jimmie H. Harvey Jr., Murat O. Arcasoy, Elizabeth O. Hexner, Roger M. Lyons, Ronald Paquette…
    Citation: Journal of Hematology & Oncology 2017 10:55
  7. The driver mutations JAK2V617F, MPLW515L/K and CALR influence disease phenotype of myeloproliferative neoplasms (MPNs) and might sustain a condition of chronic inflammation. Pentraxin 3 (PTX3) and high-sensitivit...

    Authors: Federico Lussana, Alessandra Carobbio, Silvia Salmoiraghi, Paola Guglielmelli, Alessandro Maria Vannucchi, Barbara Bottazzi, Roberto Leone, Alberto Mantovani, Tiziano Barbui and Alessandro Rambaldi
    Citation: Journal of Hematology & Oncology 2017 10:54
  8. Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have yielded unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells for B cell acute lymphoblastic leukemia (B-...

    Authors: Zhenguang Wang, Zhiqiang Wu, Yang Liu and Weidong Han
    Citation: Journal of Hematology & Oncology 2017 10:53
  9. Circular RNAs are a subgroup of non-coding RNAs and generated by a mammalian genome. Herein, the expression and function of circular RNA circ-TTBK2 were investigated in human glioma cells.

    Authors: Jian Zheng, Xiaobai Liu, Yixue Xue, Wei Gong, Jun Ma, Zhuo Xi, Zhongyou Que and Yunhui Liu
    Citation: Journal of Hematology & Oncology 2017 10:52
  10. The majority of individuals with acute myeloid leukemia (AML) respond to initial chemotherapy and achieve a complete remission, yet only a minority experience long-term survival because a large proportion of p...

    Authors: Hubert Hackl, Ksenia Astanina and Rotraud Wieser
    Citation: Journal of Hematology & Oncology 2017 10:51
  11. Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal adhesions by recruiting structural and signaling molecules involved in cell mov...

    Authors: Ana María López-Colomé, Irene Lee-Rivera, Regina Benavides-Hidalgo and Edith López
    Citation: Journal of Hematology & Oncology 2017 10:50
  12. Long noncoding RNAs (lncRNAs) have emerged as important regulators of tumorigenesis and cancer progression. Recently, the lncRNA AGAP2-AS1 was identified as an oncogenic lncRNA in human non-small cell lung can...

    Authors: Fuzhen Qi, Xianghua Liu, Hao Wu, Xiang Yu, Chenchen Wei, Xiaodan Huang, Guozhong Ji, Fengqi Nie and Keming Wang
    Citation: Journal of Hematology & Oncology 2017 10:48
  13. Many recent publications highlight the large role of the pivotal eukaryotic nuclear export protein exportin-1 (XPO1) in the oncogenesis of several malignancies, and there is emerging evidence that XPO1 inhibit...

    Authors: Vincent Camus, Hadjer Miloudi, Antoine Taly, Brigitte Sola and Fabrice Jardin
    Citation: Journal of Hematology & Oncology 2017 10:47
  14. Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. Despite considerable investigation, the pathogenesis of ITP remains incompletely understood, and for many patients, effective therapy is ...

    Authors: Lili Tao, Qingshu Zeng, June Li, Miao Xu, Jiajia Wang, Ying Pan, Huiping Wang, Qianshan Tao, Yang Chen, Jun Peng, Ming Hou, Arend Jan Gerard Jansen, Heyu Ni and Zhimin Zhai
    Citation: Journal of Hematology & Oncology 2017 10:46
  15. Previous precision medicine studies have investigated conventional molecular techniques and/or limited sets of gene alterations. The aim of this study was to describe the impact of the next-generation sequenci...

    Authors: Sophie Cousin, Thomas Grellety, Maud Toulmonde, Céline Auzanneau, Emmanuel Khalifa, Yec’han Laizet, Kevin Tran, Sylvestre Le Moulec, Anne Floquet, Delphine Garbay, Jacques Robert, Isabelle Hostein, Isabelle Soubeyran and Antoine Italiano
    Citation: Journal of Hematology & Oncology 2017 10:45
  16. The optimal monitoring schedules and cutoff minimal residual disease (MRD) levels for the accurate prediction of relapse at all time points after allogeneic hematopoietic stem cell transplantation (allo-HSCT) ...

    Authors: Ya-Zhen Qin, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Wei Han, Yu-Hong Chen, Feng-Rong Wang, Jing-Zhi Wang, Yao Chen, Xiao-Dong Mo, Xiao-Su Zhao, Ying-Jun Chang, Kai-Yan Liu and Xiao-Jun Huang
    Citation: Journal of Hematology & Oncology 2017 10:44
  17. Numerous DNA-damaging cellular stresses, including oncogene activation and DNA-damage response (DDR), may lead to cellular senescence. Previous observations linked microRNA deregulation with altered senescent ...

    Authors: João Ramalho-Carvalho, Inês Graça, Antonio Gomez, Jorge Oliveira, Rui Henrique, Manel Esteller and Carmen Jerónimo
    Citation: Journal of Hematology & Oncology 2017 10:43
  18. We developed a novel murine monoclonal antibody (mAb) against the C-terminal α-helix of the human von Willebrand factor A2, designated SZ-179. We showed that SZ-179 inhibited the interactions between VWF and A...

    Authors: Lulu Zhang, Jian Su, Fei Shen, Zhenni Ma, Yiming Zhao, Lijun Xia and Changgeng Ruan
    Citation: Journal of Hematology & Oncology 2017 10:42
  19. Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic and epigenetic abnormalities. Recent genome-wide DNA methyl...

    Authors: Yan Li, Qingyu Xu, Na Lv, Lili Wang, Hongmei Zhao, Xiuli Wang, Jing Guo, Chongjian Chen, Yonghui Li and Li Yu
    Citation: Journal of Hematology & Oncology 2017 10:41
  20. It is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues i...

    Authors: Ya-feng Li, Gayani Nanayakkara, Yu Sun, Xinyuan Li, Luqiao Wang, Ramon Cueto, Ying Shao, Hangfei Fu, Candice Johnson, Jiali Cheng, Xiongwen Chen, Wenhui Hu, Jun Yu, Eric T. Choi, Hong Wang and Xiao-feng Yang
    Citation: Journal of Hematology & Oncology 2017 10:40
  21. Methylation of N6 adenosine (m6A) is known to be important for diverse biological processes including gene expression control, translation of protein, and messenger RNA (mRNA) splicing. However, its role in the d...

    Authors: Chau-To Kwok, Amy D. Marshall, John E. J. Rasko and Justin J. L. Wong
    Citation: Journal of Hematology & Oncology 2017 10:39

    The Erratum to this article has been published in Journal of Hematology & Oncology 2017 10:49

  22. Klotho, is a transmembrane protein, performs as a circulating hormone and upstream modulator of the insulin-like growth factor-1 receptor (IGF-1R), fibroblast growth factor (FGF), and Wnt signaling pathways. T...

    Authors: Xiangxiang Zhou, Xiaosheng Fang, Yujie Jiang, Lingyun Geng, Xinyu Li, Ying Li, Kang Lu, Peipei Li, Xiao Lv and Xin Wang
    Citation: Journal of Hematology & Oncology 2017 10:37
  23. The macrophage, one of the several key immune cell types, is believed to be involved in tumorigenesis. However, the mechanism of macrophages promoting tumor progression is largely unknown.

    Authors: Yulei Chen, Siyuan Zhang, Qizhi Wang and Xiaobo Zhang
    Citation: Journal of Hematology & Oncology 2017 10:36
  24. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the cornerstone in treatment of hematological malignancies. However, relapse of the hematological disease after allo-HSCT remains a ...

    Authors: Jun Liu, Jiang F. Zhong, Xi Zhang and Cheng Zhang
    Citation: Journal of Hematology & Oncology 2017 10:35
  25. The current success of targeted inhibition against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed Death 1/Programmed Death Ligand 1 (PD-1/PD-L1, herein collectively referred to as PD) path...

    Authors: Jun Wang, Ruirong Yuan, Wenru Song, Jingwei Sun, Delong Liu and Zihai Li
    Citation: Journal of Hematology & Oncology 2017 10:34
  26. Thrombospondin-2 (TSP-2) is a secreted matricellular glycoprotein that is found to mediate cell-to-extracellular matrix attachment and participates in many physiological and pathological processes. The express...

    Authors: Po-Chun Chen, Chih-Hsin Tang, Liang-Wei Lin, Chun-Hao Tsai, Cheng-Ying Chu, Tien-Huang Lin and Yuan-Li Huang
    Citation: Journal of Hematology & Oncology 2017 10:33
  27. The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that ...

    Authors: Pei Li, Yang Yang, Hui Liu, An-Kui Yang, Jin-Ming Di, Guang-Mou Tan, Hai-Feng Wang, Jian-Ge Qiu, Wen-Ji Zhang, Qi-Wei Jiang, Di-Wei Zheng, Yao Chen, Meng-Ning Wei, Jia-Rong Huang, Kun Wang, Zhi Shi…
    Citation: Journal of Hematology & Oncology 2017 10:32
  28. The impact of the use of anti-thymocyte globulin (ATG) in allogeneic stem cell transplantation performed with HLA-identical sibling donors following fludarabine and 4 days intravenous busulfan myeloablative co...

    Authors: Marie Thérèse Rubio, Maud D’Aveni-Piney, Myriam Labopin, Rose-Marie Hamladji, Miguel A. Sanz, Didier Blaise, Hakan Ozdogu, Etienne Daguindeau, Carlos Richard, Stella Santarone, Giuseppe Irrera, Ibrahim Yakoub-Agha, Moshe Yeshurun, Jose L. Diez-Martin, Mohamad Mohty, Bipin N Savani…
    Citation: Journal of Hematology & Oncology 2017 10:31
  29. Wilms’ tumor gene 1 (WT1) expression is a well-known predictor for relapse in acute myeloid leukemia. We monitored WT1 decrement along the treatment course to identify its significant role as a marker for residua...

    Authors: Jae-Ho Yoon, Hee-Je Kim, Dae-Hun Kwak, Sung-Soo Park, Young-Woo Jeon, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong Wook Lee and Woo-Sung Min
    Citation: Journal of Hematology & Oncology 2017 10:30
  30. Epigenetics has been known to play a critical role in regulating the malignant phenotype. This study was designed to examine the expression of DOT1L (histone 3 lysine 79 methyltransferase) and H3K79 methylatio...

    Authors: Xiaoxue Zhang, Dan Liu, Mengchen Li, Canhui Cao, Dongyi Wan, Bixin Xi, Wenqian Li, Jiahong Tan, Ji Wang, Zhongcai Wu, Ding Ma and Qinglei Gao
    Citation: Journal of Hematology & Oncology 2017 10:29
  31. Tumor metastasis is an essential cause of the poor prognosis of colon cancer. DC-SIGNR is a C-type lectin that is frequently found on human liver sinusoidal endothelial cells. LSECtin, which is a homologue of ...

    Authors: Heya Na, Xiaoli Liu, Xiaomeng Li, Xinsheng Zhang, Yu Wang, Zhaohui Wang, Menglang Yuan, Yu Zhang, Shuangyi Ren and Yunfei Zuo
    Citation: Journal of Hematology & Oncology 2017 10:28
  32. Hematopoiesis is probably the best-understood stem cell differentiation system; hematopoietic stem cell (HSC) transplantation represents the most widely used regenerative therapy. The classical view of lineage...

    Authors: Fang Ye, Wentao Huang and Guoji Guo
    Citation: Journal of Hematology & Oncology 2017 10:27
  33. CBFA2T3-GLIS2 is a fusion gene found in 17% of non-Down syndrome acute megakaryoblastic leukemia (non-DS AMKL, FAB M7) and in 8% of pediatric cytogenetically normal acute myeloid leuke...

    Authors: Riccardo Masetti, Salvatore Nicola Bertuccio, Annalisa Astolfi, Francesca Chiarini, Annalisa Lonetti, Valentina Indio, Matilde De Luca, Jessica Bandini, Salvatore Serravalle, Monica Franzoni, Martina Pigazzi, Alberto Maria Martelli, Giuseppe Basso, Franco Locatelli and Andrea Pession
    Citation: Journal of Hematology & Oncology 2017 10:26
  34. Haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT) is an alternative treatment method for severe aplastic anemia (SAA) patients lacking suitable identical donors and those who are refrac...

    Authors: Lan-Ping Xu, Song Jin, Shun-Qing Wang, Ling-Hui Xia, Hai Bai, Su-Jun Gao, Qi-Fa Liu, Jian-Min Wang, Xin Wang, Ming Jiang, Xi Zhang, De-Pei Wu and Xiao-Jun Huang
    Citation: Journal of Hematology & Oncology 2017 10:25
  35. In the absence of a HLA-matched related or matched unrelated donor, allogeneic stem cell transplantation (allo-SCT) from mismatched unrelated donors or haploidentical donors are potential alternatives for pati...

    Authors: Simona Piemontese, F. Ciceri, M. Labopin, W. Arcese, S. Kyrcz-Krzemien, S. Santarone, H. Huang, D. Beelen, N. C. Gorin, C. Craddock, Z. Gulbas, A. Bacigalupo, M. Mohty and A. Nagler
    Citation: Journal of Hematology & Oncology 2017 10:24
  36. Activated protein C/endothelial protein C receptor (APC/EPCR) axis is physiologically involved in anticoagulant and cytoprotective activities in endothelial cells. Emerging evidence indicates that EPCR also pl...

    Authors: Naiara Perurena, Carolina Zandueta, Susana Martínez-Canarias, Haritz Moreno, Silvestre Vicent, Ana S. Almeida, Elisabet Guruceaga, Roger R. Gomis, Marta Santisteban, Mikala Egeblad, José Hermida and Fernando Lecanda
    Citation: Journal of Hematology & Oncology 2017 10:23
  37. To assess the efficacy and safety of fruquintinib, a vascular endothelial growth factor receptor (VEGFR) inhibitor, in metastatic colorectal cancer (mCRC) patients.

    Authors: Rui-Hua Xu, Jin Li, Yuxian Bai, Jianming Xu, Tianshu Liu, Lin Shen, Liwei Wang, Hongming Pan, Junning Cao, Dongsheng Zhang, Songhua Fan, Ye Hua and Weiguo Su
    Citation: Journal of Hematology & Oncology 2017 10:22
  38. The determinants of clinical responses after autologous hematopoietic stem cell transplantation (aHSCT) in systemic sclerosis (SSc) are still unraveled. We analyzed long-term immune reconstitution (IR) and T c...

    Authors: Dominique Farge, Lucas C. M. Arruda, Fanny Brigant, Emmanuel Clave, Corinne Douay, Zora Marjanovic, Christophe Deligny, Guitta Maki, Eliane Gluckman, Antoine Toubert and Helene Moins-Teisserenc
    Citation: Journal of Hematology & Oncology 2017 10:21
  39. Acute myeloid leukaemia (AML) with 17p abnormalities (abn(17p)) carries a very poor prognosis due to high refractoriness to conventional chemotherapy, and allogeneic stem cell transplantation (allo-SCT) appear...

    Authors: Xavier Poiré, Myriam Labopin, Johan Maertens, Ibrahim Yakoub-Agha, Didier Blaise, Norbert Ifrah, Gérard Socié, Tobias Gedde-Dhal, Nicolaas Schaap, Jan J. Cornelissen, Stéphane Vigouroux, Jaime Sanz, Lucienne Michaux, Jordi Esteve, Mohamad Mohty and Arnon Nagler
    Citation: Journal of Hematology & Oncology 2017 10:20
  40. The value of microRNAs (miRNAs) as novel targets for cancer therapy is now widely recognized. However, no information is currently available on the expression/functional role of miRNAs in diffuse malignant per...

    Authors: Rihan El Bezawy, Michelandrea De Cesare, Marzia Pennati, Marcello Deraco, Paolo Gandellini, Valentina Zuco and Nadia Zaffaroni
    Citation: Journal of Hematology & Oncology 2017 10:19
  41. Thrombocytopenia 2 (THC2) is an inherited disorder caused by monoallelic single nucleotide substitutions in the 5’UTR of the ANKRD26 gene. Patients have thrombocytopenia and increased risk of myeloid malignancies...

    Authors: Caterina Marconi, Ilaria Canobbio, Valeria Bozzi, Tommaso Pippucci, Giorgia Simonetti, Federica Melazzini, Silvia Angori, Giovanni Martinelli, Giuseppe Saglio, Mauro Torti, Ira Pastan, Marco Seri and Alessandro Pecci
    Citation: Journal of Hematology & Oncology 2017 10:18
  42. Aerobic glycolysis, a hallmark of cancer, is characterized by increased metabolism of glucose and production of lactate in normaxia. Recently, pyruvate kinase M2 (PKM2) has been identified as a key player for ...

    Authors: Zhimin Gu, Jiliang Xia, Hongwei Xu, Ivana Frech, Guido Tricot and Fenghuang Zhan
    Citation: Journal of Hematology & Oncology 2017 10:17
  43. We have previously shown that in pancreatic ductal adenocarcinoma (PDA) cells, the glycolytic enzyme alpha-enolase (ENO1) also acts as a plasminogen receptor and promotes invasion and metastasis formation. Mor...

    Authors: Moitza Principe, Simone Borgoni, Mariafrancesca Cascione, Michelle Samuel Chattaragada, Sammy Ferri-Borgogno, Michela Capello, Sara Bulfamante, Jennifer Chapelle, Francesca Di Modugno, Paola Defilippi, Paola Nisticò, Paola Cappello, Chiara Riganti, Stefano Leporatti and Francesco Novelli
    Citation: Journal of Hematology & Oncology 2017 10:16
  44. Pegylated interferon (peg-IFN) was proven by phase II trials to be effective in polycythemia vera (PV); however, it is not clear whether it could improve patient outcome compared to hydroxyurea (HU). Here, we ...

    Authors: Elena Crisà, Marco Cerrano, Eloise Beggiato, Giulia Benevolo, Giuseppe Lanzarone, Paola Maria Manzini, Alessandra Borchiellini, Ludovica Riera, Mario Boccadoro and Dario Ferrero
    Citation: Journal of Hematology & Oncology 2017 10:15
  45. The causative role of the pro-inflammatory cytokine IL-6 in prostate cancer progression has been well established at molecular level. However, whether and how IL-6 may play a role in prostate cancer risk and d...

    Authors: Gang Liu, Jinyu Zhang, Lewis Frey, Xiao Gang, Kongming Wu, Qian Liu, Michael Lilly and Jennifer Wu
    Citation: Journal of Hematology & Oncology 2017 10:14
  46. Indatuximab ravtansine is a monoclonal antibody-linked cytotoxic agent that specifically targets CD138-expressing cells. Monotherapy has been shown to significantly inhibit multiple myeloma tumour growth in vi...

    Authors: Kurt Schönfeld, Chantal Zuber, Jan Pinkas, Thomas Häder, Katrin Bernöster and Christoph Uherek
    Citation: Journal of Hematology & Oncology 2017 10:13
  47. Cluster of differentiation 47 (CD47) (also known as integrin-associated protein) is a ubiquitously expressed glycoprotein of the immunoglobulin superfamily that plays a critical role in self-recognition. Vario...

    Authors: Xiaojuan Liu, Hyunwoo Kwon, Zihai Li and Yang-xin Fu
    Citation: Journal of Hematology & Oncology 2017 10:12

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